Differential scanning calorimetry

A mathematical model was proposed describing the quantitative relationships between sugar, water and protein on the gelatinization of wheat starch following the heating in microwave for 20s as determined by differential scanning calorimetry. Sugar addition decreased the degree of gelatinization of starch due to the microwave heating. Sugar was found more effective in delaying gelatinization than the water and protein. In water-limited systems the effects of sugar and protein…

The development of new drug discovery technologies like high throughput screening, combinatorial chemistry, etc. has led to the discovery of a large number drugs that are poorly water soluble.(1,2) Approximately 40% of the NCEs are poorly water soluble and has poor bioavailability.(3) The successful clinical use of these molecules requires the application of solubility enhancement based formulation approaches. Among the various solubility enhancement technique like use of cosolvents,…

10.1 SUMMARY The aim of the present investigation was to formulate Raloxifene Hydrochloride Liquisolid compacts, with coadministration of a bioenhancer, for oral bioavailability enhancement. The reason for poor bioavailability (2%) of Raloxifene Hydrochloride is low solubility (100μg/mL) and high hepatic first pass metabolism. According to BCS, Raloxifene Hydrochloride is considered as Class II drug, lipophilic and highly permeable compound. Therefore, formulating Liquisolid Compacts bearing…

On February 6 of 2018, at 11:00 a.m. in room 1043 of Thomas Cole Research building, Sade Rhodes spoke about the characterization of lignin-coated cellulose nanocrystals (C-CNCs) as a reinforcing agent in polypropylene (PP) nanocomposites. The logistics of the seminar that was most enjoyable was when the speaker focused on the matter of Nanocelluloses. She provided a lot of information on this topic and I understand how it related to her topics in her research. However, the only part that I did…

The following analysis will be performed to determine if there was any change in the polymorphic form of the drug or to characterise and provide structure information of the physical state of the dipyridamole. X-ray diffractometry, differential scanning calorimetry and infrared…

2.2. Methods 2.2.1. Preparation of econazole nitrate nanoparticles The econazole nanoparticles were prepared by nano-spray drying technique. Weighed amounts of econazole nitrate, carriers and stabilizers (table 1) were dissolved in ethanol (10 ml) followed by spraying through the Buchi® nano-spray dryer B-90 (Büchi Labortechnik, Switzerland). The nano-spray dryer was operated using inert loop B-295 system (Büchi Labortechnik AG, Flawil, Switzerland) operated using nitrogen gas with flow rate of…

The crystal size is also affected by the rate of cooling and larger crystals were shown to be formed when fat was cooled at a slower cooling rate83. However the samples were not subjected to changes in the rate of cooling in this study. At higher temperatures (or lower supercooling conditions) due to decrease in the driving force, less crystals are formed although the crystals are larger in size as compared to those formed at lower temperatures83. At lower temperatures, due to the higher driving…

Styrene (St, 99%) and methyl methacrylate (MMA, 99%) were obtained from Aldrich company. These monomers were first dried over calcium hydride, were purified by being passed through a column of basic alumina, and were distilled under reduced pressure. Ethyl 2-bromoisobutyrate (EBIB, 98%), copper (I) bromide (CuBr, 99%), copper (I) chloride (CuCl, 99%), and other chemical reagents were procured from Aldrich company and used as received. N-methylbis[2-(dodecylthio)ethyl]amine (SNS) was synthesized…

ABSTRACT Dex-Ibuprofen–polyethylene glycol (PEG) conjugates (PEG-dex-Ibu) were organized and their prospective as a prolonged release method was investigated. PEG-Dex-Ibuprofen conjugates were synthesized as of Ibuprofen and PEG with 4000 Da molecular weights by esterification in the incidence of DCC and DMAP. The PEG-dex-Ibu conjugates were characterized by FT-IR, 1H NMR, and DSC analysis. The solubility revise in aqueous system showed an improvement within the solubility of conjugates. The…

AC conductivity: Figure 4.19(a) shows the frequency dependent electrical conductivity of PCL5 electrolyte. The result shows that AC conductivity changes with temperature. The AC conductivity of the PEO/CoCl2 electrolyte increases with temperature is given in Table 4.4, which is the common characteristic of disordered materials. An increase in ac conductivity with frequency and temperature indicates charge transported by hopping through the defect sites along the polymer chain [70]. Also the…