In conclusion, we reported the synthesis of fused and isolated triazoles based on thieno[2,3-d]pyrimidines. The synthesized 1,2,4-triazolo compounds were screened for their anticancer activity at a concentration of 10 μΜ against a panel of 60 cell lines derived from nine different types of cancers, and also screened for their PDE 5 inhibitory activity. The possibility of combining 1,2,4-triazolo moiety to thieno[2,3-d]pyrimidines should open new opportunities for the rational design of…
INTRODUCTION Oral Controlled Release Drug Delivery Systems1, 2: Oral controlled release drug delivery is a drug delivery system that provides*give the continuous oral delivery of drugs at predictable and reproducible kinetics for a predetermined period throughout the course of GI transit and also the system that target the delivery of a drug to a specific region within the GI tract for either local or systemic action. All the pharmaceutical products formulated for systemic delivery via*throw…
Chemically, polyester (or many esters) is primarily a family of polymers wherein the monomers belong to the category “esters”. The most commonly used polyester is the polymer of diglycol terephthalate and is called polyethylene terephthalate (PET). Nylon is a group of polymers, which can be classified as polyamides. Today several types of nylon are produced with properties tuned to meet customer specifications. The most commonly used ones are nylon-6 (which is manufactured from caprolactam) and…