Dichloromethane

Chemistry: Enasidenib is a first in class, a selective allosteric inhibitor of mutant isocitrate dehydrogenase-2 (IDH2) inhibitor discovered at Agios Pharmaceutical, Inc. in the United States of America. Recently, on 1 August 2017, Celgene Corporation and Agios Pharmaceutical in cooperation won the approval for Enasidenib under brand name IdhifaTm for the treatment of relapsed/refractory acute myeloid leukemia. it is a white to off-white crystalline, non hygroscopic powder existing in…

g) Solubility: soluble in methanol, slightly soluble in water (13.4 mg/ml) and very slightly soluble in dichloromethane h) Route of administration: Oral i) Excretion: kidney j) Therapeutic category: Antiretroviral drug k) Metabolism: The cytochrome P450 enzyme system is not involved with the metabolism of Tenofovir disoproxil or Tenofovir. l) pKa value: 3.75 m) Trade Name: Viread 2.2.5 Drug profile of Efavirenz: Efavirenz is an antiretroviral drug and it belongs to the class of…

The purpose of this lab was to synthesize acetanilide and use recrystallization to isolate the acetanilide product from small amounts of impurities, acetic acid. Recrystallization is a very effective way for organic chemists to isolate a solid product from a small amount of impurities but cannot be used for liquids. The crude acetanilide product and the recrystallized acetanilide were compared using melting point determination and the recrystallized product was then classified and checked for…

The cyano-ethoxy carbonyl protection Manoharan et al. (1999) developed 2(cyanoethoxycarbonyloxy)succinimide S.27a a stable, crystalline, and convenient reagent for the protection of pendant akylamines in oligonucleotides (Figure X.X.X). The 2-cyanoethyl (ce) group is the most common phosphate protecting group in oligonucleotides; however, ce and corresponding 2-(cyanoethoxycarbonyl) group were not utilized for the nucleobase protection until 2000. Merk et al. (2000) developed…

Despite the practical and informative nature of the Williamson ether synthesis of 2-bromo-4-methoxy-phenoxy benzyl ether. This reaction was not conducted due to an error made in which the initial product was thrown away instead the actual second phase of this synthesis was the Williamson Ether synthesis of 4-methoxy-phenoxy benzyl ether. Figure 4. Williamson Ether Synthesis 4-methoxy-phenoxy benzyl ether ____________________________________¬___ In spite of this outcome there was still much…

A solution of butadiene and meso-tetraphenylporphyrin (100 mg, 0.162 mmol) dissolved in dichloromethane (100 ml, 1.57 mol) in a water-jacketed flask was irradiated with compact fluorescent lamps. The solution was then concentrated in vacuo and the product subjected to column chromatography to yield the product, aldehyde, and unreacted starting butadiene…

Vinorelbine also known as Navelbine® is an anti-cancer chemotherapy drug. It belongs to a class of chemotherapy drugs called vinca-alkaloids; which can be categorised as spindle poisons1. Vinorelbine and Vindesine are semi-synthetic derivatives from the first generation of vinca-alkaloids; Vinblastine and Vincristine2. These original vinca-alkaloids were derived from dried leaves of the Madagascan periwinkle (vinca rosea) plant1. Madagascar periwinkle is also used in the treatment for diabetes,…

ABSTRACT Dex-Ibuprofen–polyethylene glycol (PEG) conjugates (PEG-dex-Ibu) were organized and their prospective as a prolonged release method was investigated. PEG-Dex-Ibuprofen conjugates were synthesized as of Ibuprofen and PEG with 4000 Da molecular weights by esterification in the incidence of DCC and DMAP. The PEG-dex-Ibu conjugates were characterized by FT-IR, 1H NMR, and DSC analysis. The solubility revise in aqueous system showed an improvement within the solubility of conjugates. The…

container with either acetone or ethanol. This process is known as Pressurized liquid extraction or PLE. In a study performed by Chulalongkorn University, charantin was extracted using several different chemicals. It was found that water and dichloromethane are less efficient than acetone or ethanol processes. Now there is a legitimate methodology to pharmacies this chemical and truly synthesize it as a drug. This compound alone can be used to treat diabetes and has the potential to replace…

This chapter discusses about the health hazard and hygiene in the workplace. Hazards can be found in every workplace. Hazard is generally anything that makes you in a dangerous situation. Health hazard is means that the hazard brings negative effect and harm to the health which is may cause measurable changes in the body. There are many hazard in the workplaces have the potential to harm workers short-term and long-term health result in diseases, disorders and injuries (Alison et. al., 2008).…