Dearborn

Introduction In vertebrates, reproduction is primarily controlled by the hypothalamus-pituitary-gonad axis. The gonadotropin-releasing hormone (GnRH) neurons in the hypothalamus are key regulators of the hypothalamic neuroendocrine system mainly though the synthesis of GnRH (Moenter et al., 2003). The decapeptide GnRH is released from the hypothalamus in a pulsatile manner, and the amplitude and frequency of these pulses change throughout the estrous cycle (McCartney et al., 2002; Moenter et al.…

Unfortunately, some companies have mismanaged their greatest asset—their brands. This is what befell the popular Snapple brand almost as soon as Quaker Oats bought the beverage marketer for $1.7 billion in 1994. Snapple had become a hit through powerful grassroots marketing and distribution through small outlets and convenience stores. Analysts said that because Quaker did not understand the brand’s appeal, it made the mistake of changing the ads and the distribution. Snapple lost so much…