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INTRODUCTION Osteoarthritis is a disease, which results from mechanical and biological events that destabilize the normal processes of degradation and synthesis of articular cartilage chondrocytes, extracellular matrix, and subchondral bone. These changes include increased water content, decreased proteoglycan content, and altered collagen matrix, all leading to the deterioration of articular cartilage. Osteoarthritis can be classified into primary and secondary types Primary osteoarthritis…

The most common bone tumors of the foot and ankle are osseous and cartilaginous lesions, including enchondromas, osteochondromas, and chondromyxoid fibromas [1]. Giant cell tumors (GCT), chondroblastomas, osteoid osteomas, and osteoblastomas also occur. Non-neoplastic conditions include intraosseous lipomas, simple (unicameral) bone cysts, and aneurysmal bone cysts [2]. GCT, also known as osteoclastomas, are fairly common bone tumors, accounting for 5% of all primary bone tumors. They are benign…

(Griffin). Calcium should primarily be acquired through food, but if a diet is lacking calcium, a supplement may be recommended by a physician. Proper calcium absorption can only take place with the assistance of nutrients, most importantly vitamins D and A (Ehrlich). Even if the right amount of calcium is being consumed, several nutrients still need to be present to actually help the bones. An example of a verily inexpensive calcium supplement is calcium carbonate. Its composition includes more…

Bone is a common site of metastases for many primarily malignant tumors, being the third location after liver and lung [5]. Bone metastases are a major clinical concern as they can deteriorate the bone structure causing pathological fractures, vertebral/spinal instability, severe pain, spinal cord compression, functional impairment and increased mortality. The vertebral column being the most frequent site of bone metastasis and one of the major organs in human body strongly correlated to neural…

If I say act like an old person you would hunch over and walk as though you needed a cane, moving as if taking a single step could break your leg. Osteoporosis is a disease of the skeletal system that causes bone deterioration, or the breaking down of bones. Making them fragile and much easier to break than normal. Anyone can developed osteoporosis but generally older women are more prone to developing it. Half of all women and about a quarter of men 50+ years will break at least one bone due to…

Michael Orr Professor Shuler Brittle Bone Disease September 22, 2014 Brittle Bone Disease Have you ever experienced an accident that resulted in a broken bone? Maybe you fell roller skating or were in an automobile accident. If you answered yes, then you know how painful it can be. Breaking a bone is not only painful, but can also be troublesome and life changing. Breaking a bone can cause one to have restricted range of motion and movement. Each bone in the skeletal system serves a specific…

Metacarpal Fracture A metacarpal fracture is a break (fracture) of a bone in the hand. Metacarpals are the bones that extend from the knuckles to the wrist. There are five metacarpal bones that connect your fingers and your thumb to your wrist. Some hand fractures have bone pieces that are close together and stable (simple). These fractures may be treated with only a splint or cast. Hand fractures that have many pieces of broken bone (comminuted), unstable bone pieces (displaced), or bone that…

Everyone needs a break once in a while but not when it comes to your bones. The older a person becomes the greater the chances are that broken bones will become a reality. As we age the changes in our diet along with the hormonal changes in our bodies causes our bones to become brittle. They are less able to handle the stress of a fall or other traumatic event we may sometimes find ourselves in. Even though most people do their best to take care of themselves often we find that may not be enough…

Calcium can be considered as one of the most used elements of the periodic table. People tend to use, eat or drink it every day even if they do not know it. The symbol for calcium is very simple: Ca. Its atomic number is 20.(Helmenstine, 2015) Calcium has 20 electrons and 20 protons because electrons and protons will always have the same amount. There are also 20 neutrons in calcium due to the subtracting of the atomic weight and the number of protons to get the number of neutrons.(Nelson,…

Osteogenesis Imperfecta Osteogenesis imperfecta, also known as “brittle bone disease”, is a genetic disorder characterized by fragile bones that break easily. Osteogenesis imperfecta is caused by a lack of collagen in the bones that affect the body’s ability to make strong bones. Collagen is the major protein of the body’s connective tissue. In dominant Osteogenesis imperfecta, a person has either a lack of type 1 collagen or a poor quality of type 1 collagen, caused by a mutation in one of the…