Cytotoxicity

The antitumor effect of nivolumab in the melanoma regiment was followed by another trial with 107 patients, where 31% of the patients had an impartial response, with a median duration for 2 years. Of these responders, 15 responded to the therapy by 8 weeks during the first assessment, 12 had continued responses for minimum of 4 months after ending the therapy, while 17 had responses but left the program unexpectedly. Now, nivolumab use has achieved an improved outcome in patients with melanoma…

INVIVO AND INVITRO STUDIES ON CHEMOPROTECTIVE EFFICACY OF RESVERATROL IN BREAST CANCER 1. INTRODUCTION 1.1 BREAST CANCER: Breast cancer is the most frequently diagnosed cancer and it is one of the leading causes of cancer death in women worldwide. Diet and Nutrition play a key role in carcinogenesis process, as reflected in the global differences in breast cancer incidence worldwide. High fat content, meat and low fiber diets were associated with high breast cancer incidence rates whereas…

Cytotoxicity assay: Cytotoxic and viability assay of pulchranin A on human cancer cell lines: The isolated compound exhibited a moderate cytotoxic effect on the three tested cell lines: HCT, HepG2 and MCF-7 where the cell viability, measured by SRB assay, and…

Phyllanthus niruri Extracts of Phyllanthus niruri have been studied for biological activities in various animal models and in vitro models and reported to possess significant antimicrobial, antiviral, hepato protective, antioxidant, anticancer, anti-inflammatory, antiplasmodial, antiurolithiatic and diuretic. The phytochemical studies were characterized and the presence of various compounds such as lignans, phyllanthin, hypophyllanthin, flavonoids, glycosinoids & tannins was mentioned (Narendra…

Bismuth is the 83rd chemical in the periodic table. It is found as a natural metal on the surface of the earth. Bi has a ground state electronic configuration of [Xe]4f145d106s26p3 and trivalent and pentavalent Bi, Bi(III) and Bi(V), respectively, are the two predominant oxidation states. [27] It was discovered over a thousand years ago but was often confused with tin and lead. It is a prevalent post transition metal, which chemically resembles arsenic or antimony. Bismuth is the most naturally…

In contrast to other drug molecules wherein P-gp sequestration renders the drug unavailable for action, lysosomal P-gp enhanced the transport of thiosemicarbazones into the lysosomes. [28]. This accounted for the increased lysosomal damage and cytotoxicity of thiosemicarbazones towards P-gp expressing tumor cells.[28] 3.3 Inhibition of Metastasis :Metastasis accounts for the maximum deaths due to cancer. NDRG1 (N-Myc downstream regulated gene 1) is a metastasis suppressor protein [30,31]. It…

What exactly degree can prepared meat lead to colorectal malignancy? Among lethal maladies which humankind has not yet completely figured out how to cure, malignancy is likely a standout amongst the most imposing sicknesses. Conflicting with Helps or different maladies generally spread in nations with low expectations for everyday comforts, growth 's geology is much wide, including both rich and needy nations impartially. Among the variety of distinctive sorts of growth, a standout amongst the…

Cancer is a disease affecting the world and the rise in treatments with drugs is just one way of delaying the process of the disease as well as improving the quality of life for the patient. Henceforth Amsacrine is one to watch out for due to its specific mode of action. Reference. Amsacrine has an acridine chromophore with an amine at the 9 position (fig 1.) used in the treatment of some types of lymphoma or acute adult leukaemia [5]. It can also be known as Amsidine or m-AMSA [1]. Lymphoma…

relationship between the occurrence of colon carcinoma and dietary deficiency of vitamin A in AFB1-fed rats (Fleming et al., 1994; Rogers & Newberne, 1975). In order to clarify the interaction between AFB1 with IECs, Watzl et al. determined the cytotoxicity and DNA-damage of jejunal epithelial cells of the Brown Norway (BN) rats induced by AFB1 in vitro and in vivo. They found AFB1 can induce genotoxicity in isolated epithelial cells of jejunum (430 mM, in vitro), but short-term oral exposure at…

substances to the immune system” (Anderson et al., 2015). Scientists believe melatonin will be effective in fighting Ebola because it “is a powerful immune regulator, increasing the generally beneficial Th1 cells and IFNg response, as well as the cytotoxicity of NK cells” (Anderson et al., 2015). If melatonin does prove to be an appropriate treatment option for Ebola, it will provide a cheap and readily available option for infected individuals. The 2014 Ebola epidemic in West Africa proved to…