Cytotoxicity

When external antigen causes disease by infection, cell-mediated immune response in our body acts as basal defense system against exogenous pathogen. Native and adoptive immune system has established to attack infected cell by recognizing major histocompatibility complex (MHC). There are two major lymphocytes related to killing effect called cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells.[1], CTLs and NK cells recognize peptide epitope present on MHC class I to find infected cell.…

INTRODUCTION Two significantly important highly pathogenic infection diseases namely Legionellosis and Influenza remains even today a threat to global health. They can cause severe community-acquired pneumonia with respiratory failure but they can also generate hospital-acquired infections.1 Moreover Legionella infection could attribute to influenza infection. The cause of influenza was definitively resolved back in 1930s with the isolation of swine influenza; a virus which when administered…

Benzene is the simplest aromatic hydrocarbon that is represented with the formula C6H6. It was discovered in 1825 by a British scientist, Michael Faraday, who extracted it from crude oil by applying pressure, and named it “Bicarburet of hydrogen”. However, its chemical synthesis did not start until in 1843, Charles Mansfield, discovered a method to extract benzene from coal tar. Since its industrialization, benzene is produced and used in many industrial processes. Today, plastics, resins, dyes…

last one of synthesized mixes were assessed for their anticancer movement against four human growth borealis lines, lung malignancy (A549), breast tumor (MCF7), cervical cancellous (HeLa), Furthermore prostate malignancy (DU145) cell lines. Those cytotoxicity outcomes indicated that (E)-3-aryl- 1-(5-(2-arylimidazo[1,2-a]pyridin-3-yl)thiophen-2-yl)prop-2-en- 1-one shown empowering inhibitory movement against the greater part four mankind's Mobile lines. (Scheme…

STUDY TITLE A Randomized, Phase 2, Two-Arm, Open-Label, Multicenter, Study of Folotyn® (Pralatrexate Injection) with and without Oral Leucovorin to Prevent or Reduce Mucositis in Patients with Relapsed or Refractory (R/R) Peripheral T-Cell Lymphoma (PTCL) BACKGROUND 1.a Defining Peripheral T-Cell Lymphomas (PTCL) Peripheral or mature T-cell lymphomas are subset of aggressive non-Hodgkin lymphomas (NHL) that comprise approximately 10-15% of all newly diagnosed cases of NHL in the United State.…

Ecological Effects of Chagas Disease and The Triatominae reduviidae By Billy John Muro For Mr. Jose Maldonado Biol 1307 December 6, 2016 Abstract America Trypanosomiasis most commonly known as Chagas disease (ChD) is caused by a protozoan parasite known as Trypanosoma cruzi. This disease affects 7 to 8 million people worldwide. Current treatments such as benznidazole and nifurtimox are partially effective and cause severe side effects, for this reason there is an urgent need to…

Results and Discussion Shellfish is considered a good indicator for environmental pollution with heavy metals, simply because it can accumulate high levels of these metals. However, these organisms are considered valuable source for animal derived protein, vitamins and essential trace elements, especially for people living nearby sea. Thus, estimating the residual levels of these metals, in particular the toxic ones, assessment of the possible human health risks and trying to find effective…

4.1 Maintenance and sub-culturing of endophytic fungi The cultures were procured from already maintained repository in laboratory. The maintenance of the cultures involved preparation of Potato dextrose agar (PDA) plates, sub culturing of cultures and long term preservation. 4.1.1 Preparation of PDA (Potato dextrose agar) plates 39g of PDA was dissolved in 1000 ml double distilled water, stirred to mix properly and was transferred into 250 ml Erlenmeyer flasks and autoclaved at 121˚C at 15…

CHAPTER 2 REVIEW OF RELATED LITERATURE AND STUDIES This chapter contains a compilation of local and foreign literatures and studies about the topic researched and are provided as a guide for the hypothesis of this research and served as a basis for the methodology of the study. These provided studies were also used to support the study and compare the difference of the present. DIABETES According to the International Diabetes Federation (2013), diabetes is one of the most challenging health…

PATH2201 Processes in Disease Media Assignment – Can Probiotics Aid in the Treatment of Coeliac Disease? Elissa Jennifer Watt (z3463000) 21/09/14 Tutor: Melanie Walker Introduction Advances in medical diagnosis and screening have revealed that coeliac disease (CD) is a major health issue across the world, affecting all ages. In Australia, the rate of CD was previously estimated to be around 0.4% (Hovell, et al., 2001). More recent estimates suggest that around 1.2% in men and 1.9% in…