Cytochrome P450

Metronidazole Systematic (IUPAC) name: 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethanol Bioavailability : 80% (oral), 60-80% (rectal), 20-25% (vaginal)122,123 Protein binding : 20% 122,123 Metabolism : Hepatic 122,123 Half-life : 8 hours 122,123 Excretion : Urine (77%), faeces (14%) 122,123 Formula : C6H9N3O3 Mol. mass : 171.15 g/mol Melt. point : 159–163 °C (318–325 °F) Metronidazole is a nitroimidazoleantibiotic medication used particularly for anaerobic bacteria and protozoa.…

Classified as a complex brain disease, SUD is treatable, according to the USA National Institute of Drug Abuse (NIDA) principles of treatment [NIDA, 2008]. Given the aforementioned multiple factors, contributing to the development of SUD, its complex presentation, and associated disease burden; treatment of SUD is rated as significantly challenging. Delivering effective SUD treatment and care requires a comprehensive response, illustrated as core services and interventions delivered, within a…

INTRODUCTION Oral Controlled Release Drug Delivery Systems1, 2: Oral controlled release drug delivery is a drug delivery system that provides*give the continuous oral delivery of drugs at predictable and reproducible kinetics for a predetermined period throughout the course of GI transit and also the system that target the delivery of a drug to a specific region within the GI tract for either local or systemic action. All the pharmaceutical products formulated for systemic delivery via*throw…