Cytochrome P450

The GCMS analysis showed the metabolites could be definitely identified as concern compound by comparisons with known authentic compound. The m+ ion is found at m/z94 for phenol. The molecular weight of the phenol is 94. The base peak value of phenol was observed as 94 and mass peak values were recorded as 66, 39, and 55. The m+ ion for acetophenone is m/z 120. The molecular weight of the compound was observed as 120, the base peak and mass peak values were recorded as 105 and 91, 77, 51, 39,…

Introduction The drugs used in this experiment are Chloramphenicol and rifampicin. Both of these drugs are antibiotics however their methods of action are quite different. These drugs have different effects on the bacteria they are being used against. Rifampicin is a bactericidal drug and chloramphenicol is bacteriostatic. Bactericidal drugs interfere with the bacteria to such an extent that the bacteria die. They not only prevent new cells from growing but also cause a crucial aspect of the…

I. INTRODUCTION: Clopidogrel is one of the major drugs used in the treatment of Acute Coronary Syndrome. Along with Aspirin it is the standard of care in Percutaneous Coronary Interventions with stenting, when a long term dual antiplatelet treatment is needed. However the response to clopidogrel shows wide inter-individual variations. Various studies have shown that the polymorphisms in the genes responsible for Clopidogrel absorption and metabolism are a major factor for these variations.…

Part 1: adverse reactions 1.1 Introduction (QT prolongation) The toxicity of antipsychotic drugs is considered a good example of specific gender differences in Adverse Drug Reactions (ADRs) in a dose-dependent manner [1]. This adverse effect is induced cardiac arrhythmia known as torsade de pointes (TdP) (delay of cardiac repolarization), are associated with the following drugs such as; chlorpromazine, mesoridazine, pimozide and thioridazone, which increase the risk of QT prolongation. It…

bitter melon any hypoglycemic drugs along with insulin, which can cause a rapid decrease in blood sugar levels when used simultaneously. It also has a known drug interaction with P-glycoprotein that increases the chance of toxicity. Lastly, any cytochrome P450 substrates are inhibited with the use of bitter melon extract because it interferes with the metabolism of the drug. The patients that should avoid bitter melon are pregnant women and children. In pregnant women, this herb can cause…

Most people could probably guess that heart disease and cancer are the leading causes of death, but many may not know that strokes are the fourth leading. Strokes are also one of the leading causes in long-term adult disability. A stroke occurs when there is a clot in a blood vessel or an artery located in the brain, interrupting or severely reducing blood flow to the brain, preventing it from getting the oxygen it needs. There are two different types of strokes, and there are multiple types…

Question 4 Answer: Smoking damages the whole body, but for this answer, I am going to focus on smoking and the changes to our respiratory tract, skin blood vessels and antioxidant levels. Respiratory tract: “(1) Nicotine constricts terminal bronchioles, which decreases airflow into and out of the lungs. (2) Carbon monoxide in smoke binds to hemoglobin and reduces its oxygen-carrying capability. (3) Irritants in smoke cause increased mucus secretion by the mucosa of the bronchial tree and…

Benzene is the simplest aromatic hydrocarbon that is represented with the formula C6H6. It was discovered in 1825 by a British scientist, Michael Faraday, who extracted it from crude oil by applying pressure, and named it “Bicarburet of hydrogen”. However, its chemical synthesis did not start until in 1843, Charles Mansfield, discovered a method to extract benzene from coal tar. Since its industrialization, benzene is produced and used in many industrial processes. Today, plastics, resins, dyes…

Drugs can be categorized into various types ranging from stimulants to depressants. Heroin is categorized as a type of opioid drug that usually appears as a white powder. Cocaine is a very addictive stimulant drug that produces short term bursts of energy and has dangerous effects such as raising the heart rate. Alcohol is classified as a depressant drug because it slows down the central nervous system causing a decrease in reaction time and intellectual performance. LSD is referred to as a…

of blood pressure? The CYP11B1 gene provides instructions for making an enzyme called 11-beta-hydroxylase. This enzyme is found in the adrenal glands, which are located on top of the kidneys. The 11-beta-hydroxylase enzyme is a member of the cytochrome P450 family of enzymes. These enzymes are involved in the formation as well as breakdown of various molecules in cells. The 11-beta-hydroxylase enzyme helps produce hormones so-called cortisol as well as corticosterone. Specifically, the enzyme…