Cysteine

There are several isoforms of this protein but the one found predominantly in muscle is the 427kDa isoform. Dystrophin is made up of four domains: an N-terminal, a rod domain composed of 24 triple helix repeats and 4 hinges, a cysteine-rich domain and a C-terminal. The N-terminal of the protein binds to actin filaments and acts as a bridge between the actin cytoskeleton and the extracellular matrix via interactions with the dystroglycan complex (DGC) in the sarcolemma in muscles…

Summary: Barry James, a 67-year-old man presents to the hospital with a recent onset of diarrhea and weight loss; patient has a history of lactose intolerance, vitamin B12 deficiency and intermittent diarrheal episodes that last 1-2 days. Peripheral edema was noted on the physical examination, and the abdominal examination was negative for distention and organomegaly. Question: Describe the pathophysiology and clinical presentations associated with small intestine malabsorption. Generate:…

According to Ph.D. holder Pramod Dash, “it has been estimated that nearly 2 million people suffer some degree of head injury every year in the United States alone.” The Centers for Disease Control and Prevention estimates that about 1.7 million people in the United States have a traumatic brain injury each year. Brain injury can be defined as something that isn’t hereditary, degenerative, or present at birth that causes damage to the brain. The most common types of brain injury are traumatic…

DNA ISOLATION INTRODUCTION: Deoxyribonucleic acid (DNA) isolation is an extraction process of DNA from various sources. Methods used to isolate DNA are dependent on the source, age, and size of the sample. Despite the wide variety of methods used, there are some similarities among them. In general, they aim to separate DNA present in the nucleus of the cell from other cellular components. Isolation of DNA is needed for genetic analysis, which is used for scientific, medical, or forensic purposes…

P. aeruginosa is a gram-negative non-sporulating bacillus that belongs to the phylum of Proteobacteria. It can adapt and thrive in different niches, ranging from water/soil to plant/animal tissues. Even though it is commonly found in the environment, it frequently causes infections in plants and animals (1). Luke (1862) was the first to report P. aeruginosa in infections as he observed rod-shaped particles in blue-green pus of some infections. This coloration is a hallmark of P.…

To demonstrate the synergistic effect of the MWCNTs@PpPD-PB nanocomposites, cyclic voltammetry (CV) was used for characterizing the electrochemical properties of the composites modified GCE in N2 saturated 0.1 M KCl (pH2.7) aqueous solution at a scan rate of 50 mVs-1. Fig. 5 shows the CVs of the pristine GCE, GCE/MWCNTs, GCE/MWCNTs@PpPD, GCE/MWCNTs-PB, and GCE/MWCNTs@PpPD-PB in the absence of H2O2. The reversible pair of redox peaks are observed for MWCNTs-PB (Fig. 5(d)) and MWCNTs@PpPD-PB…

react with an enzyme. The choice of the suitable group for the activated PEG derivative is based on the type of available reactive group on the molecule, to which PEG will be conjugated. For proteins, typical reactive amino acids include lysine, cysteine, histidine, arginine, aspartic acid, glutamic acid, serine, threonine, tyrosine as well as N-terminal amino acid group and the C-terminal carboxylic acid. Among them, lysine and N-terminal amino acid groups are the most used for the protein…

INTRODUCTION Lovastatin is a statin drug that decreases the total cholesterol level in patients diagnosed with hypercholesterolemia. The drug aims to prevent serious cardiovascular diseases such as heart attack due to blockage of arteries. Lovastatin acts as a competitive inhibitor for the HMG-CoA reductase enzyme in catalyzing the conversion of HMG-CoA to mevalonate, (Alberts, 1998). The drug is also hydrolyzes in vivo to active form β-hydroxyl acid, (Katz, 2005) and was recently researched on…

Being an omnivore comes along with a couple of benefits like being a high-quality source of protein, collecting important minerals, and vitamins that are needed throughout our bodies; however, being an omnivore can also lead to health problems, a large amount of wasted resources, and can create pollution. Each person can identify themselves by the certain types of diets that are dispersed all around us; there are a variety of diets that even seem unorthodox, yet the ones that we hear about the…

Researchers have identified 3 common amino-acid-polymorphisms associated commonly with red haired people viz., R160W, R151C, & D294H. The abbreviated names mean common amino acid types were found in positions 160 151, & 294 in proteins are arginine (R), cysteine (C), arginine & aspartic acid (D), while amino acids histidine (H) & tryptophan (W), were found in the redheads (Catherine A Guenther, 2016). Many rare polymorphisms of amino acid are there in MC1R genes, some may be linked to red hair.…