Creatinine

Disease Name and other derivatives Lesch-Nyhan disease is a genetic disorder which causes neurological and behavioral abnormalities. Overproduction of uric acid is another clinical feature associated with this disease. The disease is also known as Lesch-Nyhan Syndrome, HPRT Hypoxanthine Phosphoribosyl Transferase) deficiency syndrome and X-linked hyperuricemia. Michael Lesch and William Nyhan provided the first detailed clinical description of Lesch-Nyhan disease in 1964. Gene and Locus and…

The development of Zurampic®(Lesinurad), a first selective uric acid resorption inhibitor to treat gout Summary: Gout is the most common inflammatory arthropathy in the western world, which is caused by the excess accumulation of uric acid in the blood instead of normally excreting by kidney. Millions of people suffer from this kind of arthritis with an attack of sudden burning pain, stiffness, and swelling in a joint(usually a big toe). However, the current treatment for gout is far from…

- In multiple myeloma, mild hemolytic anemia can be seen, whereas in SPB the hemoglobin levels are normal. Elevated creatinine and blood urea nitrogen are seen in multiple myeloma; the renal involvement isn’t present for SPB. High levels of monoclonal protein in serum and urine are indicative of multiple myeloma. The SPB typically has absent or low serum or urinary levels…

An independent 72-year old man , MR. Allan, presented to the emergency department with progressively increasing shortness of breath (SOB) over the past few months .Initially shortness of breath was exertional , but increased to shortness of breath at rest. He had an ongoing cough for one week. My essay will begin with a review of his presenting condition, patient history and symptoms on arrival to Intensive care unit. I will also look at the patient investigations and assessment findings. MR…

among these are diabetes mellitus and hypertension. At present, analysis of renal brokenness is in view of such estimations as creatinine, urea, and electrolytes, and additionally on creatinine freedom. These circuitous estimations have low affectability, since a critical change in creatinine level is just perceptible after a 60% capacity misfortune has happened, while creatinine leeway overestimates the genuine glomerular filtration rate (GFR) by up to 20%. Furthermore, these clinical science…

Result and Discussion The concentration of serum alanine aminotransferase (ALT)(IU/L), aspartate amino-transferase (AST)( IU/L), Alkaline Phosphatase (ALP)(U/L), Serum creatinine (mg/dl), Serum albumin concentration (g\dl), Serum urea concentration (mg/dl) in all subjects were clarified in the table and figure (1). Depending on the result in the table , a significant (P0.05) differences in mean values of serum urea concentration in all Volunteers. The liver is the most…

nephrotoxicity. Nephrotoxicity is a significant adverse effect of the calcineurin inhibitors, cyclosporine, and tacrolimus. Nephrotoxicity can be divided into acute and chronic effects. Acute nephrotoxicity typically manifest as a rise in the serum creatinine, hyperkalemia and a decrease in urine output, particularly when cyclosporine or tacrolimus levels are above the normal therapeutic range. Clinical Features:…

required to fulfill the 1982 ACR revised criteria for SLE and have active/refractory disease manifestations, detectable anti-dsDNA antibodies and low C3 or C4 serum levels; exclusion criteria were severe lupus nephritis (proteinuria > 6 g/24 h or creatinine > 2 mg/dl), severe active neuropsychiatric lupus, potentially life-threatening SLE manifestations and ongoing or planned pregnancy. Clinical scores (i.e. SLEDAI-2K score, SELENA-SLEDAI Flare Index, SLICC/SDI score), daily prednisone…

was scheduled for a CT Abdomen with contrast media (CM) administration. There is no detail information on CM history, but the patient reported with lower limb swelling, high blood pressure and high protein in the urine. A recent test on BUN and creatinine level also was high. She is currently on a medication. Condition of patient Based on the sign and symptoms that be mention erlier this patient might be suffer from the chronic renal failure. According to Melissa, 2007, chronic renal failure…

Introduction: Postmenopausal women have a greater risk of developing chronic kidney disease (CKD) in later life [1]. Estrogen is nephroprotective in premenopausal women; however, it has been suggested that the loss of estrogen predisposes women to reduced kidney function [2]. As a consequence, there is an increased risk of incident mild cognitive impairment (MCI) and dementia, which has been demonstrated by several studies [3-5]. The risk of incident cognitive impairment and dementia are…