Clostridium difficile

Thank you for you information request on Florastor® (Saccharomyces boulardii) and prevention of Clostridium difficile. As you stated earlier, Ms. JS was recently transferred from another facility to Llano Estacado Estates for a higher level of care. JS is an 84 year old, female patient that has been diagnosed with Alzheimer’s dementia, anxiety, depression, insomnia, hypothyroidism, constipation, and gastro-esophageal reflux disease (GERD). She is currently on the following medications: Aricept®…

to treat antibiotic-associated Clostridium difficile. In recent years there has been a marked increase in the number of patient with recurrent C. difficile infections or CDIs, presumably due to the increase in antibiotic use by the population. Treatment for an initial C. difficile infection is antibiotics. For mild to moderate infections the antibiotic metronidazole also known by the brand name Flagyl is widely used, though it is not FDA approved to treat C. difficile infection. Taken multiple…

Clostridium difficile (hereafter C. Difficile) is a bacteria that contributes to many diseases, the spectrum of disease can range from mild cases of diarrhea to more life threatening cases like pseudomembranous colitis to toxic megacolon (Kelly 2008). Since the 1970s the use of certain antibiotics such as clindamycin to treat other infectious diseases was shown to lead to more toxic strains of C. difficile. Starting in the 1980s, cephalosporins, were the new drug of preference to treat other…

Philadelphia, PA, United States: Elsevier Health Sciences. Chopra, T., & Goldstein, E. J. C. (2015). Clostridium difficile infection in long-term care facilities: A call to action for Antimicrobial stewardship. Clinical Infectious Diseases, 60(suppl 2), S72–S76. doi:10.1093/cid/civ053 Gerding, D. N., Muto, C. A., & Owens, Jr., R. C. (2008). Measures to control and prevent Clostridium difficile infection. Clinical Infectious Diseases, 46(s1), S43–S49. doi:10.1086/521861 Retrieved October 14,…

Ever since the begging of time the medical practice has been in a fight with infections and disease control. From the early era of hospitals patients were at times in the same bed as another patient, thus spreading disease from one to another. A Hungarian obestritician by the name of Ignaz Semmelweis found and adovacted on the importance of hand washing. However, it was not until a physician by the name of Joseph Lister who created a spray to use while conducting surgery, thus being…

This study was appraised using the CASP systemic review checklist to determine the validity of the study. The review had a clearly defined problem that was easily discernible. The intervention that was used for the purpose of this review was probiotics as a method to minimize AAD. Additionally, the authors of the study used the appropriate type of papers to include in the systematic review. Only RCTs were included in the review. The population identified were adults and children who had been…

1. Describe what may occur if hepatotoxicity and nephrotoxicity occur as a result of drug use. Hepatotoxicity is when the liver detoxifies and metabolizes foreign chemicals in the blood. It can be damaged by drugs or their metabolic products. If liver cells are injured, enzymatic abnormalities usually occur which is when fatty liver deposits form, hepatitis occurs, and in the worst cases liver failure can result. Nephrotoxicity occurs when nephron tubules and/or filtration abilities of the…

World renowned scientist Alexander Fleming said, “It is the lone worker who makes the first advance in a subject, the details may be worked out by a team, but the prime idea is due to enterprise, thought, and perception of an individual” (“Alexander”). Following his own advice, Fleming noticed something inhibiting bacterial growth in his petri dish and extracted the substance. Fleming discovered penicillin, the world’s first antibiotic that would eventually save countless numbers of lives…

Natalie Buttaccio Biol 251 Oliphant January 20, 2017 1. According to Bonnie Bassler in the video TedTalk, the human body is considered 90% prokaryotic because there are ten times more bacterial cells than human cells on a human being. Humans have approximately 30,000 genes, but you actually have ten times more bacterial genes. Bassler considers humans about 90% bacterial. These bacterial cells literally almost do everything, from digesting our food, making our vitamins, keeping us healthy, etc.…

placed in a patient to replace the beneficial bacteria that have either been killed or suppressed. This is currently effective in the treatment of dysbiosis caused by Clostridium difficile. FMT have been shown to have 90% efficacy with the first round of treatment. Compare this to the 84% efficacy of first-round treatment of C. difficile through antibiotic treatment and the 40% efficacy of antibiotic treatment after multiple relapses. Secondly, personalized culture collections are communities of…