Clinical trial

took in EBP- from framing the clinical question then performing the literature search in various electronic databases and applying the rules of evidence to establish validity of the study and finally to relate the findings to the patient’s clinical problem (Guyyat et al., 2000). The Clinical Question For this discussion, the author has formulated a foreground question (Jewell, 2015). The author wishes to study the effectiveness of a particular intervention. The clinical question is: Does the…

The process of developing new drugs typically involves clinical trials. When a new medication, vaccine, or similar product has been developed, researchers must ensure that they are effective and safe for people to use. To experimentally test that a drug produces the intended effect, most clinical trials use a randomized controlled trial (RCT) design. In this type of experiment, some people are assigned by chance to the active intervention and others are assigned by chance to a controlled…

One might assume that counterfeit pharmaceuticals wouldn’t pose as such a large problem due to stringent government programs such as the FDA. But, unfortunately, these drugs sneak under the FDA radar and aren’t regulated in the slightest. The FDA is the Food and Drug Administration and it is responsible for monitoring the safety, efficacy, quality and security of a variety of products distributed across America and other US territories. Their aim as an organization is to inform and educate…

Nhat Duong Does Ginger have an effect in relieving nausea and vomiting during pregnancy? A natural root of a plant called Ginger (Zingiber officinale) belongs to a Zingiberaceae family including cardamom and turmeric that are mostly cultivated in tropical areas.1(p373) The primary component of ginger called gingerol comes from the root of the plant and its spicy aroma mainly due to the present of ketones called gingerols.1(p132,),2 Ginger is widely consumed in diet as a flavor in cooking and…

arthritis, neuralgia and related conditions, chronic rhinosinusitis, cardiovascular disease, and urinary tract infections. However, U. dioica shows the most promise in treating BPH and has several clinical trials to support its use and prove its efficacy (Urtica dioica; Urtica urens (Nettle), 2007). In these trials it was found to relieve the symptoms that BPH causes in the lower urinary tract, including the constant urge to urinate, inadequate emptying of the bladder, reduced urinary flow, and…

Sorafenib: Sorafenib is used as targeted therapy for those patients affected by papillary thyroid cancer or medullary thyroid cancer. In a phase III trial, patients were subjected to a double blind, randomized experiment, in which patients were effectively treated with surgery or RAI previously. However, these eligible patients had distant metastatic sites, and were RAI-refractory, which are remnants of cancerous tumors found elsewhere in the body that were not treated in their previous…

The Effectiveness of Deep Breathing Exercises on Pulmonary Function One of the first frameworks nursing students learn in school is the importance of assessing the patient’s airway, breathing, and circulation (ABCs). These three concepts are critical for survival, and alteration of any of these can result in death. Chronic obstructive pulmonary disease (COPD) involves two conditions: emphysema and chronic bronchitis. Emphysema is characterized by the loss of lung elasticity and destruction of…

with humans and animals. However, the article also describes how after 12 weeks, there are no evaluations done to show the effects of long term use. “We should be cautious when interpreting the results as other randomized, placebo-controlled clinical trials have not reported the same outcomes (Fabiola, Babio, Bullo, & Salvado, pg. 585).” Studies on humans are done on small samples and on a short term (12weeks). The article states there is little evidence to support the effectiveness form the…

ethics committee discuss how to determine what is ethical in this circumstance. There were questions from clinical staff at one point, does allowance of experimental clinical trial drug give the patient and family false hope. The drug was to help the patient in the clinical study to cope emotionally. The family had a moral standard, yet how much financial loss occurred from using the clinical trial. What about the other patients whom may have needed to use the experimental drug? Ethically the…

‘Big pharma’ refers to global pharmaceutical and biomedicine companies that lobby governments, media and other entities to expand their influence. In spite of being responsible for the modern innovations in medical devices and drugs, progress for research and development for new drugs or treatments is painstakingly slow. Like software updates or patches, the development for treatment has seen incremental therapeutics, such as small changes to existing formulations but rarely does the public see…