Clearance

It has always been a problem and it still is: trucks getting wedged or clipped by low clearance overpasses and bridges. Some bridges are hit so many times that they're often referred to as "can openers." Why does this keep happening? There are many reasons for low clearance collisions such as inexperience, distraction, fatigue, or a momentary lapse in focus that causes the commercial or owner operator truck driver to not see the "cars only" or "no trucks" sign when driving on an unfamiliar route…

current Unclogerall® purification process at the Boston Production Facility (BPF), a viral clearance filtration step must be introduced into the manufacturing process. The proposed viral reduction step would be added after the last purification column step and prior to the final formulation of the drug substance. A laboratory scale study was completed and concluded that the addition of a viral clearance filtration step to the Unclogerall® manufacturing process reduces the viral risk level to…

upper management, managers and oh yeah, do not forget the Federal Government. Differences and variations in processes are parts of realities that are dealt with daily. One particular process or procedure that keeps everyone frustrated is the clearance process. FSOs are hired to manage the entire security program of a company and be the a liaison between the company and the government. In actuality, a FSO wears two hats, one where he or she performs the required security functions for the…

Calculating these clearances are very important in practice because depending on the drug, you may need to make dose adjustments so that the patient avoids drug toxicity and is benefitting from the drug itself. For example, if a patient is given a drug that is cleared at 6 L/hr but has 50% renal impairment, I would have to calculate what both the original hepatic and renal clearances were and then account for the 50% reduction in renal clearance to find the new total clearance. Let’s assume that…

The glomerular filtration rate (GFR) filters the plasma through the glomerulus capillary blood pressure and into the Bowman’s capsule hydrostatic pressure (Sherwood, 2007, pp. 508-509). The filtrate subsequently travels into the proximal tubular so that sodium absorption occurs. The tubular reabsorption is the filtrate that flows through the tubules and the substances of value returns to the perutubular capillary plasma into the blood stream (Sherwood, 2007, p. 506). Such that the body can…

person each day containing environmental stimuli including pathogens and particles such as toxic pollutants and allergens. These must be expelled from the body as it may induce airway inflammation and infection, causing airway diseases. Mucociliary clearance acts as an innate defence against these stimuli, where cilia is a part of this mechanism. Cilia, microscopic organelle extensions, beat orderly to propel mucus with embedded substances out of the respiratory system. When this mechanism…

With the expansion of technology and the Internet, people fiercely protect their online identity to include regularly changing and safeguarding online passwords, upgrading security scans to keeps computers protected from viruses. However, personal and sensitive information exists online, and it is vulnerable even when safety measures are in place. This vulnerability led to a compromise of the Office of Personnel Management (OPM) database and sensitive information was obtained by…

(AUC0∞) was estimated using the trapezoidal rule and adding C/k_el , where C is the last concentration used in the trapezoidal calculation, and kel is the elimination rate constant. The increase in AUC for carvedilol was related to the decrease in clearance for rats given CCl4 in all three treatment groups compared to control. The carvedilol plasma concentration was higher in rats with liver fibrosis. According to the concentration vs. time profiles, the tmax seems to be around 2 hours.…

When dealing with patients with Cystic Fibrosis it is important to know what education materials are needed for the patients and their families, whether it is in a hospital, a home, or in a specialized program. Some facilities in particular, will have educational materials online so that the patient’s families can print them out and review the material. The education materials will include instructions on how to perform the following: active cycles of breathing techniques, autogenic drainage,…

time with or without notice. If an employee’s performance, attendance or conduct falls below The Infinity Arenas standards, disciplinary action may be taken. Discipline may consist of any number of procedures, including but not limited to: counseling, warnings, demotion, transfer, suspension (with or without pay), or termination of employment. The Company maintains the sole discretion to respond to any situation that may lead to discipline in whatever manner it deems appropriate, without regard…