Chromosomal translocation

It affects the lymphatic system, which helps your body fight infections. There are two common types: Sporadic and Endemic. The types differ by the parts of the body affected and the geographic location. Cause: The disorder is caused by chromosomal translocations. It is also associated with impaired immunity. The endemic (African) type is linked to the Epstein-Barr virus, HIV, and malaria. Malaria weakens the immune system’s response to Epstein-Barr, which allows it to change infected B-cells…

Chromosomal inheritance relates to how a person has 2 sets of chromosomes, 46 in total, that they inherited their parents. Chromosomes carry the genes, particularly the alleles that the offspring inherit. Gregor Mendel had no understanding of chromosomes when conducting his studies. He experimented and tested peas and discovered that some genes were dominated (showed up) while others were recessive (hidden). What he didn’t know was that chromosomes contained the genes that were responsible for…

Down syndrome (or Down’s syndrome) is a generic chromosomal disorder which is caused by the presence of an extra chromosome 21. It is also known as “trisomy 21”. This condition leads to deficiencies in both cognitive ability and physical growth. It is typically related with physical growth delays, characteristic facial features, and minor to moderate intellectual disability. The IQ level of an adult decreases because of this. This genetic disorder, which differs in severity, sometimes causes…

lymphoid precursor cells, also known as lymphoblasts. During the early development of these cells, they experience an interruption of their cell development. This is usually due to an abnormal gene expression, mostly caused by chromosomal translocation. Chromosomal translocation happens because of a chromosome abnormality that occurs in the rearrangement of the nonhomoglous chromosomes. The lymphoblasts then replace the normal elements in the bone marrow causing a decrease in production of…

infectious diseases, heart abnormalities, and fluctuating levels of mental retardation, in most cases severe. Information on Down syndrome, including signs, symptoms, and diagnosis; genetic information such as a detailed description on trisomy 21, and translocation; an expanded and comprehensive history on Down syndrome; modern-day individuals…

Genetic Disease Project: Trisomy 21 What is Trisomy 21? For starters, Trisomy 21 is another for a genetic disease called Down Syndrome. Genetic Home Reference says “Trisomy 21 is a chromosomal condition that is associated with intellectual disability, a characteristic facial appearance, and weak muscle tone (hypotonia) in infancy. All individuals affected experience cognitive delays, but the intellectual disability is usually mild to moderate. You get Down Syndrome by having a extra set of…

C-myc is a transcription factor that is involved in the strict regulation of the cell cycle. It regulates genes that promote the induction of the cell cycle and it is also involved in apoptosis. The c-myc ¬gene is one of the most commonly activated oncogenes and has been found to be overexpressed in many cancers. Activation of this oncogene may contribute to as many as 100,000 cancer deaths per year in the United States alone (Dang et al., 2006). The discovery that this gene is involved in so…

Non-Hodgkin’s Lymphoma (NHL) is a type of cancer that originates in the lymphatic system, the system in the body that is responsible for fighting disease, and is known to be the 6th most common cause of cancer death.1 There are many different types of lymphoma and is classified based on multiple factors such as the pathophysiology of the disease, how the disease metastasizes to other organs and its response to treatment. The two main types of lymphoma are NHL and Hodgkin’s Lymphoma. Hodgkin’s…

chromosomes and some with 47. The cells with 47 chromosomes contain the extra 21 chromosome. Scientific studies have shown that individuals with mosaic down syndrome have less characteristics of down syndrome than other types of down syndrome. Translocation, which only accounts for around 4% of cases of down syndrome, the total number of chromosomes in the cells stays 46. However, an additional full or partial copy of chromosome 21 clings to another chromosome, most commonly chromosome…

their doctor that their baby has been diagnosed with Down Syndrome. People born with this condition often struggle with health issues and social skills. Down’s is a chromosomal disorder that causes lifelong health and intellectual issues depending on its severity. Unfortunately, “Down syndrome is the most common genetic chromosomal disorder and cause of learning disabilities in children” (Mayo Clinic Staff). It not only influences how one functions and communicates in everyday life, but Down…