Cholestasis

against APAP hepatotoxicity appear to be mediated by inhibiting the oxidative stress and subsequent JNK activation. Some previous studies have reported that bcl-2 over-expression in hepatocytes protects against injury induced by hepatectomy [38], cholestasis [39], ischaemia/reperfusion [40] and Fas ligand [41]. Unexpectedly, bcl-2 overexpression has been shown to enhance APAP hepatotoxicity [42]. In harmony with this finding, nilotinib reduction in APAP hepatotoxicity might be linked to the…

Sarcoidosis was first mentioned by J. Hurtchinson in early 1869, and was thought to be a dermatological condition based on a patient he had seen. During that summer, he visted Christiania (now Oslo, Norway), and viewed a compilation of pathological drawings, including one of a healthy, Swedish sailor, a patient of C.W. Boeck. The sailor had skin lesions comparable to those of Hutchinson's original patient. However, unlike Hutchinson's original patient, this one did not suffer from gout. In…

Hepatitis is an inflammatory disease of the liver. The term hepatitis is most often used in conjunction with viral hepatitis, but the disease can also be caused by bacteria or toxic injury to the liver. It should be noted that whether hepatitis is bacterial, viral, or toxic, this disease can result in post necrotic cirrhosis, unless the hepatitis responds to treatment. Viral hepatitis is by far the most important liver infection and is a major health problem in the United States. The term viral…

For centuries both men and women have had an obsession with physical fitness and physique. An athlete’s goal in the gym is to become a stronger, faster, and more physically fit individual in order to excel at his or her sport and best the competition. A bodybuilder’s goal may be to isolate certain muscle groups and maximize his growth and definition in order to achieve higher scores at competitions. An average gym attendant’s goals may be any combination of these. With that said, for decades…

Anemia in SCD patients can be caused by problems with the spleen known as splenic sequestration crisis and aplastic crisis. In splenic sequestration crisis the red blood cells become stuck in the spleen making it enlarge rapidly. Because these cells are trapped, there are fewer cells to circulate through the blood, resulting in anemia. Aplastic crisis occurs when a common infection known as Parvovirus B19 is caught. Parvovirus is a common infection in childhood also known as fifths disease, a…

acne, deepened voice, and baldness. Some of the hormonal effects in females may be irreversible. Aside from reproduction in the male and female, steroids are harm to the liver. Side effects regarding the liver may include hepatocellular damage, cholestasis, peliosis hepatis, hepatoadenoma, hepatocarcinoma, cardiovascular and hematologic effects, increased cholesterol, hypertension, and thrombosis. Benign and malignant tumors have been associated with the distribution of steroids. Many athletes…

Wilson Disease is also known as Hepatolendicular Degeneration. “Wilson Disease (WD) is an autosomal recessive disorder that results in accumulation of copper in the liver as a consequence of mutations in the gene encoding the copper- transporting P-Type ATPASE (ATP7B)” (Wooton-Kee et al.,2015). Wilson Disease is inherited and begins between the early mid ages, affecting very few people. This disease is not common and is a very rare disease. Wilson disease starts as a result of copper poisoning…

red-sage, tickberry. Is an invasive species. Present in many different colors depicting it’s maturity level. Can grow in variety of climatic conditions and soil. Is known to be toxic to livestock. Ingestion by grazing animals causes intrahepatic cholestasis and associated liver damage. Keywords: Lantana camara, antioxidant enzymes , catalase , ascorbate peptidase , phenolics. Introduction 1. About the genera- Kingdom-…

Plenty of Athletes in sports today use steroids. Not all of them get caught, but when they do it’s a big price to pay. Most athletes think steroids are worth the risk, but they really aren’t. Although steroids help a minority of professional athletes increase their physical strength and performance, the media reports show professional sports are dominated by the majority who use steroids to get an advantage. Many athletes use steroids, and drug test are always catching people. Most healthy males…