Chirality

Benzimidazole and its derivatives were synthesized according to the reported literature (Wagner EC et al., 1943). The compounds are benzimidazole ;1-(4-((1H-benzimidazol-1-yl) methylamino) phenyl) ethanone; 2-butyl-1H-benzimidazole; 2-methyl-1H-benzimidazole. The stock solutions are prepared by dissolving the compound in DMSO. Antimicrobial activity was tested by the disc-diffusion method under standard conditions using Mueller-Hinton Agar (MHA) and the antibiotics used as listed below, Table…

Introduction: Limonene is a terpene that can be isolated from orange peels almost 100% in the (R)-(+)-limonene form. The essential oil from the orange peel belongs to terpenes, which are compounds that are made up of two or more five carbon units, named isoprene.1 The limonene is a monoterpene, which means it is made up of two isoprene units. Natural products are related compounds formally derived from isoprene units are terpenoids.3 The skeleton of terpenoids may differ from strict additivity…

Biopharmaceutics This is the in-vivo or in-vitro study of various physiochemical factors including developmental and design factors affecting the rate and extent of drug absorption with regards to the pharmacological effect of the drug. Biopharmaceutical studies use this result to improve likely problems that could arise from poor drug absorption and increase the bioavailability of newly formulated drugs. The main purpose of biopharmaceutical studies is to increase, monitor and maintain the rate…

Introduction Stereochemistry alludes to the science that reviews the properties of stereoisomers. It can likewise be characterized as the branch of chemistry concerned about the three-dimensional course of action of particles and atoms and the impact of this on concoction responses. A critical branch of stereochemistry is the investigation of chiral atoms. Stereochemistry is otherwise called 3D science in light of the fact that the prefix "stereo-" signifies "three-dimensionality". The primary…

Aim: Discuss the advantages, disadvantages and limitations of mass spectrometry for the analysis of both small molecules and proteins. Background Mass spectrometers. They are a powerful tool used to evaluate analytes such as single atoms, molecules, whole proteins, or the simple peptide chains that make them up. Using the mass to charge ratio (m/z) of these analytes, we can differentiate one or many entities (such as one particular peptide fragment, or a panel of them) from everything else in…

AHHHH CHOO-DOEPHEDRINE Although, originally defined as the chemistry of biological structures, organic chemistry has since been redefined to refer specifically to organic (carbon based) molecules. The hydrocarbon is the very basic molecule of organic chemistry and by adding functional groups to the hydrocarbon we can manipulate the properties of the molecule. Through the manipulation of these organic compounds, organic chemistry can be used to chemically synthesise many products such as soaps,…