Chemical synthesis

In conclusion, we reported the synthesis of fused and isolated triazoles based on thieno[2,3-d]pyrimidines. The synthesized 1,2,4-triazolo compounds were screened for their anticancer activity at a concentration of 10 μΜ against a panel of 60 cell lines derived from nine different types of cancers, and also screened for their PDE 5 inhibitory activity. The possibility of combining 1,2,4-triazolo moiety to thieno[2,3-d]pyrimidines should open new opportunities for the rational design of…

different types of kidney stones, each with different chemical structures. The formation of different types of kidney stones is dependent on the chemical nature of the stone, or precipitate. The solubility of precipitate, its concentration, and the presence of other chemicals are all characteristics that are related to the…

ABSTRACT: Terpolymer / kaolinite microcomposites were synthesized by 2:2:1 molar ratio of aniline, anthranilic acid and o-phenylenediamine monomers, respectively using various percentages of kaolinite clay via modified in situ oxidative ter-polymerization. The results were confirmed by FT-IR and UV-Vis absorption spectra of terpolymers / kaolinite composites. The thermal behaviour of the terpolymer and composites was studied. Terpolymers / kaolinite composites were thermally more stable than…

used as the host fluid for nanofluid synthesis. The dispersion of nanoparticles in a base fluid has been done either by a two-step method or by a single step method. In either case, a well-mixed and uniformly dispersed Nanofluid is needed for successful reproduction of properties and interpretation of experimental data. As the name implies the two step method involves two stages, first stage is the processing of nanoparticles following a standard physical or chemical method and in the second…

The objective of Chapter 6: Compounds and Elements was to determine how to synthesize and decompose pure substances, distinguish the difference between compounds and elements, and to determine the difference between complete and incomplete reactions. Previous chapters that contained valuable background knowledge were Chapter 2: Mass Changes in Closed Systems and Chapter 5: The Separation of Mixtures. The Law of Conservation of Mass, which was tested in Chapter 2, proved to be vital in this…

MYCOCEPT (Mycophenolate mofetil) is the 2-morholinoethyl ester of mycophenolic acid (MPA). CHEMICAL NAME: 2-morpholin-4-ylethyl (E)-6- (4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4 enoate. STRUCTURAL FORMULA: Fig: Mycophenolate mofetil MOLECULAR WEIGHT: 433.50g/mol APPEARANCE: Mycophenolate mofetil, is a white to off-white crystalline powder. SOLUBILITY: It is slightly…

Our initial investigation of the asymmetric Mannich reaction of indole 2a with phenyl α-amidosulfone 3a is summarized in Table 1. The effect of catalyst structure on the reaction outcome was first investigated at 10 mol% catalyst loading in toluene (Table 1, Entries 1–5). As we expected, based on our knowledge of the catalytic performance of chiral oligoEG 1,[7] the ether chain length (Entries 1–3) as well as suitable acidity of the phenolic protons (Entry 2 vs. Entries 4 and 5) are critical for…

reported. The theoretical spectrograms for FT-IR spectra of the title molecule have been constructed. The 1H and 13C nuclear magnetic resonance (NMR) chemical shift of the molecules are calculated by the gauge independent atomic orbital (GIAO) method and compared with experimental results. Further, density functional theory (DFT) combined with quantum chemical calculations were done to find out the first-order hyperpolarizability. The calculated HOMO and LUMO energies shows that charge transfer…

Contrary to the title, the discovery of astatine was anything but a momentary process. Many scientists discovered different astatine isotopes, atoms with the same number of protons but differing numbers of neutrons, but were unable to either reproduce their results or keep the isotope in existence for any useful amount of time. After decades of possible discovery and rediscovery, astatine was officially included in the periodic table of elements with the abbreviation At and an atomic number of…

As macromolecular machines, enzymes conduct their designated work in the confined and crowded spaces inside living cells. How does a protein work in such a condition? Functions of proteins are strongly dependent on their structural stability and dynamics while the (macro) molecular interactions are arguably affected by the complexity and diversity of their environments. To date, two interrelated cellular conditions — ‘macromolecular crowding’ resulted from the effect of volume exclusion by…