Channelopathy

This article is about the hypothesized neurological disorder. For other uses, see Panda (disambiguation). PANDAS Streptococcus pyogenes 01.jpg Streptococcus pyogenes (stained red), a common group A streptococcal bacterium. PANDAS is hypothesized to be an autoimmune condition in which the body's own antibodies to streptococci attack the basal ganglion cells of the brain, by a concept known as molecular mimicry. Classification and external resources Specialty Neurology ICD-9-CM 279.49 Patient UK PANDAS MeSH C537163 Orphanet 66624 [edit on Wikidata] Pediatric autoimmune neuropsychiatric disorders associated with Streptococcal infections (PANDAS) describes a hypothesis that there exists a subset of children with rapid onset of obsessive-compulsive disorder (OCD) or tic disorders and these symptoms are caused by group A beta-hemolytic streptococcal (GABHS) infections.[1] The proposed link between infection and these disorders is that an initial autoimmune reaction to a GABHS infection produces antibodies that interfere with basal ganglia function, causing symptom exacerbations. It has been proposed that this autoimmune response can result in a broad range of neuropsychiatric symptoms.[2][3] The PANDAS hypothesis was based on observations in clinical case studies at the US National Institutes of Health and in subsequent clinical trials where children appeared to have dramatic and sudden OCD exacerbations and tic disorders following infections.[4] There is supportive evidence for…

VASOVAGAL SYNCOPE 3 Vasovagal Syncope It starts with a feeling of whirling sensation, followed by blurred vision, and a muffled sense of hearing, until one unknowingly wakes up on the floor, wondering what had happened. This type of syncope is the classic movie scene when someone receives shocking news and passes out (Team, 2015). As scary as it is, this type of fainting is quite common in the United States. Vasovagal syncope is a result of a sudden drop in heart rate and blood…

Syncope "Syncope is defined as an abrupt, transient loss of consciousness and postural tone with spontaneous recovery, most often caused by loss of cerebral oxygenation and perfusion referred to as cerebral ischemia. Syncope is also referred to as transient loss of consciousness (Grimes, 2014)." Syncope is considered the most common medical emergency in dental offices around the world (Grimes, 2014). It can most likely occur when blood pressure is too low (hypotension) and the heart is not…

The genetic in hereditary hemiplegic migraine has furnished important comprehension a channelopathy, and now providing to a growing list of membrane excitability disorganize. (lee and Kim, 2005, p. 8) Neurotransmitters in brain is stimulate neurons to awake. Inside the skull, discomfort sympathetic is primarily confine to the meningeal blood vessels, which are densely innervated by nociceptive sensory afferent fibers of the ophthalmic division of the trigeminal nerve.(Pietrobon and Striessing,…