Caspase

4.2 RES as activator of sirtuins and other biological target structures There are several molecular activities discussed that should convey the health-promoting effects of RES. In one of the most important (if not the decisive one) study, it was shown that RES modulates the activity of the silent mating type information regulation 2 homolog 1 (SIRT1) (3). SIRT1 belongs to a protein family consisting of seven (SIRT1-SIRT7) individual members that are unique Nicotinamide adenine dinucleotide…

Participation in disease progression A variety of diseases including stroke, atherosclerosis, diabetes, ischemic heart diseases and neurodegenerative diseases are caused from the disturbances in mitochondrial functions. The production of peroxynitrite occurs either within mitochondria or may achieved from extra mitochondrial compartments. Peroxynitrite inhibits Mn-SOD by nitration (MacMillan-Crow LA and Thompson, 1999) and thus checking the breaking of nearby formed superoxide that further…

I-Kappa-B-alpha which is often abbreviated IkBa is a protein whose role is to mask the nuclear localization signals to inhibit the NF-kB (nuclear factor kappa beta) proteins by keeping them in inactive states and isolating them in the cytoplasm, this inhibits the NF-kB transcription factors and blocks the NF-kB transcription factors from binding with DNA. NF-kB is a protein complex that is responsible for controlling cytokine production, transcription of DNA, cell survival, and plays a key role…

components into surrounding tissue (121). Key players that help mediate necrosis include ROS, Calcium ions, poly-ADP-ribose-polymerase (PARP), and lysosomal proteases (888). PARP is an enzyme that is responsible for repairing DNA damage, such as strand breaks. Cells that have undergone a traumatic cellular insult typically have damaged DNA. PARP will deplete cellular ATP in an attempt to repair the massive damage to DNA. Several proteases are activated by increased cellular calcium ion…

Introduction The immune system is a collection of cells, tissues and molecules that protect our body from toxins and microbes in the environment. It serves as our defense against molecules that our body does not recognize as its own. This system contains two divisions: the innate immune system and adaptive immune system. Both systems differ in the types of cells produced and the time and length in mounting a response. Inflammatory bowel disease is a chronic inflammatory disease including…

This shows Onychonycteris finneyi, a bat fossil. The image shows its wing digits widely spread out with small claws on tip of each finger. It also shows the long tail found in earlier bat fossils (Moskowitz, 2008). Molecular Mechanisms The origins of bats wing muscles, molecular and cellular mechanisms are unknown but this research shows that the wing muscles of bats come from “a multiple myogenic source of different embryonic origins” (Tokita, Abe, && Suzuki, 2012). The results conclude that…

Background: Polycystic Kidney Disease (PCKD) is the most frequent inherited renal cystic disease around the world. PCKD is a very complex group of disorders characterized by the formation and growth of multiple renal cysts, containing urine-like fluid, which displace renal tubules and frequently leads to end stage renal disease (ESRD). PCKD has two major forms and can be transmitted as autosomal dominant or recessive traits with variable expression. 1-3 Major advances have been done towards…

2.1. Artificial Insemination (AI) : Development of techniques for successful. .freezing of spermatozoa has progressively evolved over the. . Past 60 years (Kucuk et al., 2014). At the starting of 20th century Ivanov started studying on artificial insemination (AI) of sheep’s, where Ivanov’s .studies on extenders and reproduction resulted in the development and the practical application of AI in farm animals, reviewed by (Bohlooli et al., 2012). AI provides. .many advantages to farmers and…

INTRODUCTION Cancer can be defined as a special kind of illness that occurs when the cells in a given part of a body begin to grow out of proportion than is normal. Currently, in the United States, this disease is the second leading cause of deaths. Human beings over the history have had tumors and remedies have been implemented, and others continue to be performed and studied over time (American Cancer Society, 2010). These methods of treatment include chemo-preventive methods and of late…