Caspase

Concerning nanotechnological consumer products, the most rapidly growing is the use of nanoparticles (NPs).(47) So far the knowledge regarding the safety aspects of NPs is still in its initial phase and greater efforts is needed to understand the interaction of NPs with the human body. (48) Several studies have reported that NPs always showed more serious toxicity than bulks and suggested that their size and the dose were the key factors influencing NPs toxic effects.(49) Despite of this, large…

Introduction Doxorubicin, an anthracycline antibiotic, is commonly used as an effective antineoplastic agent, in the treatment of various of malignancies, including leukemia, lymphoma, and solid tumors. Unfortunately, the clinical use of this drug is limited by cumulative dose-dependent cardiotoxicity, which may cause irreversible and severe effect of cardiomyopathy [1] The specific mechanisms of doxorubicin (DOX) induced cardiotoxicity are complex and although decades of research on this drug,…

being phagocytized, it triggers the assembly of the cytosolic NACHT-LRR-PYD-containing protein (NALP)3 (cryopyrin) inflammasome protein complex in the intracellular (Doherty, 2009; Moi, Sriranganathan, Edward, & Buchbinder, 2013) . In addition, the caspase-1 activation is activated which causes the Il-1B to mature and release into the phagocytes which cause the MSU crystal-induced NALP3 inflammasome protein complex assembly to be suppressed high concentrations microtubule inhibitor colchicine.…

Approximately seven and a half million Americans have psoriasis. For the past twenty years, scientists have been unable to find a single gene directly linked to psoriasis. Researchers from Washington University School of Medicine in St. Louis have identified the first gene directly linked to plaque psoriasis (Arbanas, 2012). Plaque psoriasis is a chronic skin condition characterized by dry, raised red patches covered with white flaky scales that can be itchy and painful. These patches typically…

Cancers are managed through effective nutrition to supplement drugs, and it is generally believed that good nutrition is effective in preventing and minimizing cancer. Indeed, many plant products including complex carbohydrates have been proven to have bio-functional role, including anti-proliferative, autophagy and apoptosis activity [25,26]. Pectin, especially modified pectins have been found to possess anticancer activity. The most well-known pectin in cancer therapy is modified citrus pectin…

The majority of the ten thousand genes that have appeared in the last forty thousand years appear devoted to strengthening our immune system. One gene, caspase ten, works directly with our immune system against bacteria. A version of the co-receptor of the HIV virus (CCR5) protects people almost completely from the particle. This genetic variant can be found in thirteen percent of the population of Western…

INVIVO AND INVITRO STUDIES ON CHEMOPROTECTIVE EFFICACY OF RESVERATROL IN BREAST CANCER 1. INTRODUCTION 1.1 BREAST CANCER: Breast cancer is the most frequently diagnosed cancer and it is one of the leading causes of cancer death in women worldwide. Diet and Nutrition play a key role in carcinogenesis process, as reflected in the global differences in breast cancer incidence worldwide. High fat content, meat and low fiber diets were associated with high breast cancer incidence rates whereas…

Busulfan is anticancer drug caused variety of adverse effects for cancer patients. It’s used to treatment of chronic leukaemia but it could cause damage to the male reproductive system as one of its adverse effects. This study aim to investigate the effect of L-carnitine and L-arginine on semen quality, oxidative stress parameters, caspase3 and testes cell energy after busulfan treatment. Materials and Methods: thirty-two adult male rats were divided into four groups. Group I (Control)…

Papillomaviruses are thought to have two methods of replication: • Stable replication of the episomal genome in basal cells • Runaway, or vegetative, replication in more differentiated cells to generate progeny virus. “Viral multiplication is confined to the nucleus. Consequently, infected cells exhibit a high degree of nuclear atopia. Koilocytosis (from Greek koilos “empty”) describes a combination of perinuclear clearing (halo) with a pyknotic or shrunken (raisinoid) nucleus and is a…

Parthenolide and STAT: It is previously discussed that the activation of STAT directs to cell proliferation, cell migration, transformation, apoptosis, cellular differentiation, adhesion, fetal development, inflammation, and immune response. In normal homeostasis, STAT tyrosine phosphorylation is short-term, lasting from 30 minutes to several hours, where as in numerous cancer cell lines and primary tumors it is in contrary to that of normal homeostasis. It takes place due to the deregulation of…