Carboxylic acid

Ferhan Abdullah Thursday, 09 November 2016 Experiment 7 The Separation of Three Organic Compounds by Acid-Base Reactions and Liquid-Liquid Extractions Abstract: The purpose of the experiment was to isolate the three mixtures 9-fluorenone , benzoic acid and benzocaine by the liquid-liquid extraction method and the acid-base reaction technique. Using the acid-base reaction technique, the acid and base are neutralized, producing salt and water. By using the liquid-liquid extraction method, two…

g) Solubility: soluble in methanol, slightly soluble in water (13.4 mg/ml) and very slightly soluble in dichloromethane h) Route of administration: Oral i) Excretion: kidney j) Therapeutic category: Antiretroviral drug k) Metabolism: The cytochrome P450 enzyme system is not involved with the metabolism of Tenofovir disoproxil or Tenofovir. l) pKa value: 3.75 m) Trade Name: Viread 2.2.5 Drug profile of Efavirenz: Efavirenz is an antiretroviral drug and it belongs to the class of…

A simple, economic, selective, precise, accurate and sensitive HPTLC method for analysis of Cilnidipine and Chlorthalidone, as a bulk drug and in formulation, was developed and validated according to ICH guidelines. The method employed HPTLC aluminium plates precoated with silica gel 60F-254 as the stationary phase while the solvent consisted of Toluene: Methanol: Ethyl acetate (8:2:0.1 v/v/v). The system was found to give compact spot for drug (Rf value of Cilnidipine and Chlorthalidone was…

one of the basics is aspirin, also referred to as acetylsalicylic acid. There are many different reactions that can be conducted in order to synthesize aspirin. One way being the Fischer esterification, which is a reaction between an alcohol and a carboxylic acid within the presence of a catalyst, synthesizing an ester (Weldegirma, 2014). The catalyst has to be something that will provide the addition of a proton, such as a Lewis acid, in order to provide a more reactive electrophile and speed…

Organic Acids An organic acid is an organic compound with acidic properties. The most common organic acids are the carboxylic acids, whose acidity is associated with their carboxyl group –COOH. Sulfonic acids, containing the group –SO2OH, are relatively stronger acids. Alcohols, with –OH, can act as acids but they are usually very weak. In general, organic acids are weak acids and do not dissociate completely in water, whereas the strong mineral acids do. Lower molecular mass organic acids such…

Diels-Alder Reaction Objective: The objective of this lab was to do a diels-alder reaction using anthracene, maleic anhydride, and xylene to create 9,10-dihydroanthracene, 10-, -succinic acid anhydride. Experimental: Anthracene (1.00g, 5.61x 10-3 mol), maleic anhydride (0.75g, 7.61x 10-3 mol), xylene (5mL, 4.71x 10-2 mol), and a stir rod were added into a round-bottomed flask. The round-bottom flask was then moved to the hood where the it was attached to a distillation column, placed on…

naming tetrahydrocarbazoles having the significant biological properties. The newly substituted tetrahydrocarbazole derivatives were prepared from substituted phenylhydrazine and cyclohexanone in glacial acetic acid under reflux. These intermediates on reaction with substituted aromatic acid chlorides in alkaline media finally converted to N-Substituted tetrahydrocarbazoles. Fifteen compounds are synthesized and charaterized by their melting point (MP), IR, NMR, MS and elemental analysis. All…

p-toluenesulfonic acid (APTS) led to the formation of 3,5-disubstituted-1,2,4-oxadiazoles 4a-f in good yields (51‒70%). The acidiccleavage of the menthone chiral auxiliary30a-d in 4c-e was achieved by acetolysis, in a mixture of Ac2O/AcOH and with a catalytic amount of H2SO4. After neutralization with 5M NaOH added dropwise, the methylamide-isoxazolidines 5c-d were obtained in 60 and 57% yields, respectively, from 4c-d, while the N-acetyl-methylamide-isoxazolidine 5e was obtained in 68% yield…

In order to extract aspirin, caffeine, and acetaminophen from a tablet of pain medication acid and base extraction techniques were used to exploit the differences in solubility between the components. This is achieved by using a separatory funnel and three different solvents, 4M HCl which separated the caffeine, deionized water which separated the acetaminophen, and 5% wt/vol NaHCO3 which separated the aspirin. Once the solution of the crushed tablet and ethyl acetate was mixed with a solvent in…

aspirin from salicylic acid and acetic anhydride. The general theory behind this experiment was to study the synthesis of a drug from organic materials. During the experiment, esterification had occurred between reactants salicylic acid and acetic anhydride. Then, phosphoric acid would catalyze the reaction and water would be added to decompose the remaining acetic anhydride. Through the process of filtration, aspirin crystals were collected and separate from the liquid acetic acid-water…