Burkholderia mallei

The Burkholderia Taxonomy and Genomics Burkholderia pseudomallei (Bp) belongs to the Burkholderia genus which contains over 40 species that inhabit a variety of ecological niches. The majority of species within this genus are non-pathogenic soil-dwelling bacteria, but a few species are highly pathogenic to humans and can result in severe disease [1]. This includes B. mallei, an obligate mammalian pathogen and the causative agent of glanders, which primarily affects horses and other solipeds and is highly virulent in humans. A clinically important species of Burkholderia is B. cenocepacia, which is a major cause of opportunistic infections in patients with cystic fibrosis [2, 3]. The genus also includes the Bp-like strain B. thailandensis,…

copies of secretion systems including three evolutionary T6SS clusters; named H1-H3-T6SS gene clusters, making P. aeruginosa an ideal organism to study T6SS (Figure 1) (5). 1.4 The Type VI secretion system The T6SS is one of the most recent examples of secretion systems. Almost 25% of all sequenced Gram-negative bacteria have gene clusters encoding T6SS (6). T6SS has been shown to play an important role in pathogenicity towards eukaryotic host cells in a variety of important human pathogens,…

2005–20095 Viruses Cercopithecine herpesvirus 21 10 Crimean-Congo hemorrhagic fever 8 EEE 4 Ebola 1 4 Lassa 2 1 Marburg 25 2 Monkeypox Hemorrhagic fever viruses 368 9 Flexal Guanarito Junin 21 1 Machupo 1 1 Sabia 2 Central European encephalitis Far Eastern encephalitis Kyasanur Forest disease 133 Omsk hemorrhagic fever 5 4 Russian spring and summer encephalitis 8 Hendra Nipah Rift Valley fever 47 66 Venezuelan equine encephalitis 146 1 Bacteria…