by solubility equilibrium method. It is done by stirring an excess of drug in the solvents water, methanol, ethanol isopropyl alcohol for a prolonged period until equilibrium is reached. It is also done in various concentrations of pH buffers. Bulk density:…
angle of repose, h= height of cone, r= radius of cone base. Bulk density: Take about 100 gm of lansoprazole microparticles into a dry 250 ml cylinder. The cylinder was filled carefully and level of powder was adjusted without compacting and the unsettled apparent volume (Vo) was noted. Bulk density was calculated, in g/ml [13]. By using the formula: Bulk density = M/Vo Where, M = weight of the sample taken, Vo = bulk volume Tapped density: Accurately weighed quantity of powder was introduced…
Preformulation Study Preparation of calibration curve of Amoxicillin trihydrate [51,53,76] Preparation of stock for Hydrochloric acid Stock solution in 0.1N Hydrochloric acid (0.1N HCl): 10 mg of Amoxicillin was accurately weighed and transferred into 10 ml volumetric flask. It was dissolved and diluted to volume make up to mark with 0.1N HCl to give stock solution containing 1000 µg/ml, after than 1ml take to from 1000 µg/ml and dilute to volume make up to mark of 10ml volumetric flask with…
However, the molecules in the surface of the solution experience less intermolecular force because part of it is exposed to a different phase. Therefore, there is a tendency for the “bulk” solution to pull the molecules from the surface towards them. This concept is applied in a rain droplet, where because of the pull by the bulk part of the solution, it shapes into a form of a sphere – a shape with the least surface…
layers, which are the part of TMM simulation, is located between SiO2 pyramids and the flat bulk of Silicone, as it is shown at…
ceramics and its correlation with pressure. It a first order process where powder pores elimination rate is correlated to the number of pores present. The rate of volume reduction increases as the number of pores decrease. Heckel equation relates the density, pressure and the pore fraction of the powder [16],. This was expressed mathematically as: If the compaction is achieved by plastic deformation and there is no particle rearrangement, heckel plot will give a straight line, but…
Energy Dispersive X-ray Spectroscopy (EDX) analysis was done by using the EDX system supplied with the FESEM. The bulk density (ρB) of the composite was determined using the relation: ρ_B=m/(〖πr〗^2 t) where m is the mass, r is the radius and t is the thickness of the pellet. The X-ray density of the composite is given by the formula, ρ_x (composite)=(M_1+M_2)/(V_1+V_2 ) where M_1 is (1-x) times molecular weight of BFO and M_2 is x times molecular weight…
EXPERIMENTAL RESULTS The present study was undertaken to formulate Solifenacin succinate immediate release tablets. The study involves preformulation studies of drug excipients, formulation and processing development along with evaluation of tablets made with the optimized formulation. Finally tablets were evaluated by in-vitro methods. 6.1. Drug excipient compatibility study Table 1. Results of compatibility study S.No. Name of Excipient Ratio of API/ Excipient Initial…
produced in the (DIWF) demonstration is actually from the bulk water onto which the dry ice is placed and not the atmospheric water vapor. In a bid to understand the mechanism of the formation of fog, the writer employs a model, where the interaction of dry ice with other liquids is closely observed, and the effectiveness of experimental conditions in producing fog…
Marine Traffic Density Over Port Klang, Malaysia Using Statistical Analysis Of AIS Data: A Preliminary Study Introduction Port Klang Malaysia is the major logistic hub of Malaysia and one of the busiest ports in South East Asia region. There are a large number of vessels or cargo ships transporting using the waterway in Port Klang Malaysia. Group [1] reported that in the first half of 2012 Port Klang Malaysia handled 5 million Twenty- Foot Equivalent Unit (TEU) of container traffic in total,…