Bcl-2

The Hills Have Eyes was Wes Craven's second directorial film after The Last House on the Left (I'm not counting his stint as Abe Snake directing The Fireworks Woman). Much like The Last House on the Left, The Hills Have Eyes has a gritty, low budget, violent look, having been shot on 16mm film. Given the budget of approximately $230,000, Wes Craven was able to craft a violent, sometimes humorous horror film that to this day is still quite popular among the horror crowd. The film has gone on to…

November is National Diabetes month, which aims to spread awareness and education about a disease that impacts millions of Americans. Diabetes is a disease that affects the entire family, especially when a child is diagnosed. Every year, 13,000 kids are diagnosed with type 1 diabetes and more than 1 million American live with the disease every day. Type 1 diabetes is categorized as an autoimmune disease in which the body’s pancreas does not make enough insulin. Insulin helps the body convert…

What is glycogen storage diseases type I (GSD1)? Glycogen Storage disease type I (GSD1) is the most common type of glycogen storage disease detected in most people. An inherited defect in the enzyme glucose – 6 – phosphatase (G6Pase) is the sole cause of this metabolic disease. GSD1 can be categorized even further into two sub categories based on its location and other defects, GSD type Ia and GSD type Ib. Without G6Pase properly functioning, there would be a break in the final step of…

Primary adrenal insufficiency (also known under the eponym Addison’s disease) occurs when the adrenal glands situated on top of the kidneys produce inadequate amounts of glucocorticoid and mineralocorticoid hormones. Autoimmune destruction of the aforementioned glands is the most common cause of primary adrenal insufficiency in the developed countries, whereas tuberculosis is the second most frequent cause worldwide. A plethora of autoimmune comorbidities can be associated with primary adrenal…

The Dipeptidyl peptidase 4 (DPP-4) inhibitors, are one of the newest anti-hyperglycemic drugs for the treatment of type 2 diabetes mellitus. Conventional anti-hyperglycemic drugs exhibit inadequate efficacy, a short duration of activity, and side effects such as hypoglycemia, weight gain, and digestive symptoms. Therefore, these drugs are associated with problems regarding safety and tolerability. In 2006, the US Food and Drug Administration approved the dipeptidyl peptidase-4 (DPP-4)…

NTD or neural tube defect is a congenital malformation resulting due to the failure of the neural tube to close during embryonic development. NTD is caused because of disturbance in the one carbon metabolism pathway. Deficiency of nutritional factors like folate, Vit B2,B6,B12 , involved in one carbon metabolism. Many loci on genes which have been associated with one Carbon metabolism has been identified and associated with risk on NTD. B vitamins and other dietary factors interact with one…

diabetes in check. "The presence of type 1 and type 2 diabetes is strongly correlated with the development of micro-vascular complications, including retinopathy, neuropathy, and nephropathy. It also causes macro-vascular complications, such as cardiovascular disease, peripheral vascular disease, and stroke. When compared to a person without diabetes, a person with type 2 diabetes has a 10–15 fold increased risk of lower-limb amputation and a 2–4 fold increased risk of dying from a myocardial…

energy when insulin helps the latter in getting into our cells (MedlinePlus, 2016), high sugar level is detrimental to a person's health. There are two type of diabetes: (i) type 1 diabetes where in the body can no longer produce insulin; and (ii) type 2 diabetes, the most common type, which hinders the body from making use of insulin accordingly (MedlinePlus, 2016).Diabetes management programs are made in order to improve a person’s lifestyle and decrease higher sugar levels. Included in these…

BRIEFING: DIABETES AMONG BLACK, LATINO, AND NATIVE AMERICAN POPULATIONS TO: CHAIR, SPECIAL COMMITTEE ON HEALTH DISPARITIES, NC GENERAL ASSEMBLY FROM: JANEL GRANT, DATE: SEPTEMBER 19, 2015 Executive Summary The burden of diabetes is more prevalent among minorities than the white population. While minorities are more likely than whites to be diagnosed with diabetes, the rates of difficulties differ by disease and minority group. Diabetes is detrimental among the Black, Latino, and Native…

Approximately 28 million people in the United States have type 2 diabetes. It is a chronic disease that affects how the body digests and processes glucose. The disease has no cure but can be managed. Managing the condition can help to prevent or delay the complications that are associated with diabetes. The pancreas produces a hormone, called insulin, that allows cells to turn glucose into energy. In people with type 2 diabetes, the cells become resistant and no longer respond to the insulin…