Autoimmunity

disease and 15 type 1 diabetes loci (Smyth et al. 2008). With the results from the subjects, researches chose nine single-nucleotide polymorphisms who has the highest prevalence of celiac disease from 11 non-HLA regions associated with this disease and 21 non-HLA regions associated with type 1 diabetes (Smyth et al. 2008). With these results, three celiac disease loci had a connection with type 1 diabetes: RGS1 on chromosome 1q31, IL18RAP on chromosome 2p12, and TACAP on chromosome 6p25 (Smyth et al. 2008). While two loci of type 1 diabetes were found on celiac loci: CCR5 and PTPN2 (Smyth et al. 2008). From the overall results of this experiment, researchers have concluded that these genes found on both disease loci can be classified as autoimmunity genes because of their prevalence in type 1 diabetes and celiac disease, thus a genetic connection between the two disorders (Smyth et al. 2008). In other studies, scientist concluded that type 1 diabetes related autoantibodies are exhibited in ¼ patients with celiac disease (Holmes 2008). Through many trials and research, the conclusion can be made that celiac disease and type 1 diabetes do have genetic similarities, however the question if one leads to the other is still up in the air. As well as both being auto immune disorders, they also share four alleles that researchers found comparing DNA in the trial mentioned earlier (Smyth et al. 2008). The four alleles are RGS1 on chromosome 1q31, CTLA4 on chromosome 2q33,…

The drive home from Children’s Hospital was the worst. It was a rainy day about thirteen or fourteen years ago, my mother was sobbing talking on the phone with my father. That was the day I was diagnosed with Autoimmune hearing loss in my right ear. To this day I can still remember that drive in the rain, seeing the old cookie cutter Busch Stadium and asking my mom what was wrong in an effort not to cry. Having autoimmune hearing loss has led to me developing my work ethic, me being in constant…

Chapter 1 Summary In chapter one it talks about how hemachromatosis is a hereditary disease and it’s the most common genetic disease for people of European descent, in which the body can't register that it has enough iron. So it keeps absorbing as much of it as possible, and this can have very, serious side effects (including death). Iron is very important for bacteria, cancer, and other things to grow. The way this disease is most easily treated is blood letting. Looks like all those crazy…

Autoimmunity and the Endocrine System Chad Martin Nursing 631 Grand Canyon University December 12, 2015 Introduction The immune system in the human body is protection. Protection not only from infectious disease processes and foreign bodies but from ourselves. The immune system is great to have when working well, however, there can be unintended and serious consequences when the system fails and initiates inappropriate responses to our bodies own cells. Autoimmunity specifically is the…

Autoimmunity is the immune system over activity that begin producing antibodies to attack the body’s own tissues instead of fighting infections. The most common evidence of autoimmune response post TBI was reported as hypothalamic-pituitary autoimmunity (APA){Guaraldi:2015bc}. Recently, autoimmunity trigged by other released GFAP, MBP, S100b and glutamate receptor have been observed in human TBI{Cox:2006wo, Sorokina:2009ud, Zhang:2014ju}. Although an increasing evidences show post-TBI…

The Human immune system and Autoimmunity The human immune system is a true strong-hold and defender, which response firmly and swiftly to attacks from foreign invaders. It has the ability to manipulate change in order to optimize the response and quarantine many of the unwanted intrusions. The Human immune system has many purposes. They include, defending the body against infectious microorganisms, such as fungi, bacteria and viruses-by destroying and resisting them. The Human immune system is…

The disease is neither contagious or genetic and it mostly affects men who are over 60 or women who are under 40. The National Institute of Neurological Disorders and Stroke has recently been doing a lot of research regarding Myasthenia Gravis. For example, a more timely and accurate diagnoses for the disease has been discovered, ss well as new therapies which have improved management of the disorder. Scientists also have an overall better comprehension of the structure and function of the…

Autoimmunity is the system of immune responses of an organism against it own cells or tissues. Autoimmune disease is when the immune system mistakenly decides parts of the body as harmful cells and builds responses targeting it’s own healthy cells. There are many different autoimmune diseases, each affecting the body in different ways. One can have the same autoimmune disease as the other but it may show different symptoms. One of the prominent autoimmune diseases is Lupus, also known as…

differentiation of auto reactive and self-antigen specific cells to enter the periphery. The self-antigen specific T cells usually recognize myelin antigens located in the CNS such as MOG, PLP, and MBP. These activated cells, through an unknown mechanism, diffuse through the blood brain barrier (BBB) and attack myelin components located in the CNS, causing lesions in the brain and spinal cord. A large discussion about genetic susceptibility is centered on the HLA-DR15 haplotype, which encodes…

1. Biliary atresia is a childhood chronic, progressive liver problem that can be acquired or congenital. This abnormality affects females slightly more often than males, and Asians and African Americans more often than Caucasians. The bile ducts, which would normally allow bile liquids to drain into the intestines and kidneys, are blocked. This blockage of bile, which aids in digestion, causes liver damage, and in turn, affects many vital body functions. Symptoms are noticed one to six weeks…