Arginine

Discussion We have carefully evaluated anti-inflammatory and anti-arthritic activity of Mangiferin (NF-κB inhibitor) and its interactions with low dose of NO modulators (L-NAME and L-Arginine) for the treatment of adjuvant-induced experimental arthritis in rats. Maximum anti-inflammatory and anti-arthritic activity of Mangiferin was observed in rats treated with Mangiferin 30 mg/kg. Its protective effect was potentiated by combination with low dose of NO modulator L-NAME (10 mg/kg). Treatment…

Muckle-Wells syndrome (MWS) is a rare genetic disorder that causes hive-like skin rashes, chills, fever, partial or total hearing loss, swollen joints, loss of kidney function, and can eventually lead to amyloidosis in some patients. Muckle-Wells syndrome is named after Thomas J. Muckle and Michael V. Wells who first described the disease in April of 1962 [1]. Muckle-Wells is in a family of diseases called Cryopyrin-Associated Autoinflammatory Syndromes (CAPS) which all are related because they…

Methylphenidate, commonly known as Ritalin, is a commonly prescribed central nervous system stimulant used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy. Medical use of methylphenidate began in 1960 and an estimated 2.4 billion doses are prescribed a year. Methylphenidate is thought to act through the inhibition of dopamine and norepinephrine transporters in neurons, especially those of dopaminergic pathways of the brain. The dopaminergic pathways of the brain are…

QUESTION 8. Describe fiber restricted diet. When would you suggest the physician prescribe this diet? Why should the patient only follow this diet for a short (temporary) period of time? Fiber restricted diet considers limitation of food intake with high amount of fiber. High fiber foods are fruits, vegetables and grains. Usually this diet prescribed for patients with bowel surgery, narrowed bowel after infectious disease or tumor action. This diet helps to reduce the amount of undigested food…

Fragile X syndrome (FXS) is identified as the leading monogenic cause of autism and congenital mental retardation. It is estimated that the frequency of FXS is 1/7000 males and 1/11,000 women (Hunter et al., 2014). In Australia, since one child is born with Fragile X every week, around 1 in 3600 boys and in 4000 – 6000 girls suffers this syndrome with the higher severity in boys. Position of the causative gene for FXS named fragile X mental retardation gene 1 (FMR1) was found at the diagnostic…

Chemistry: Enasidenib is a first in class, a selective allosteric inhibitor of mutant isocitrate dehydrogenase-2 (IDH2) inhibitor discovered at Agios Pharmaceutical, Inc. in the United States of America. Recently, on 1 August 2017, Celgene Corporation and Agios Pharmaceutical in cooperation won the approval for Enasidenib under brand name IdhifaTm for the treatment of relapsed/refractory acute myeloid leukemia. it is a white to off-white crystalline, non hygroscopic powder existing in…

It can be argued that “… the origin of life is the origin of replication” (Lane, 2010). This statement proves to be correct to a certain extent as if there were to be any mutations within the stages of replication, the life created could have abnormalities which may decrease quality of life experienced. Sickle cell anaemia is a hereditary form of anaemia in which a point mutation causes the formation of haemoglobin which distorts the erythrocytes into a sickle-shape (Appendix 1). The sickle…

The low-density lipoprotein (LDL) receptor is an important protein in human function. LDL receptor is the main protein that binds and carries cholesterol to maintain homeostasis in mammalian cells. In human plasma, it is also the most abundant cholesterol-carrying lipoprotein (Goldstein and Brown, 1987). It plays a major role in the development of atherosclerosis, a chronic disease caused by the accumulation of LDL-cholesterol in the blood. The LDL receptor is also the main protein that is…

The Impact of Protein In order for the human body to function properly, an individual needs a variety of different sources. Proteins are considered a key source that is needed in the human body and are essential to one’s diet. This is true because proteins inhabit a spot in every cell in an individual’s body. Therefore, individual’s need to consume a large amount of protein in order to maintain good health. Proteins are essential to a variety of different functions for one’s body but are said to…

Puberty is considered to be a period of transition consisting of both physiological and morphological changes when an individual becomes a fecund adult from a juvenile. All mammals undergo puberty (1) although the precise timing of this event is different for each species. Pubertal onset, in mammals, is governed by the pulsatile release of gonadotropin-releasing hormone (GnRH) from the hypothalamus. GnRH promotes secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from…