Apoptosis

Additionally, this mutation prevents cells from dying off through a process called apoptosis, even if they begin to exhibit properties that would normally prompt them to do so. Such behavior is a product of a specific altercation in the cells’ section of genetic code responsible for producing a protein called “AKT1 kinase”, which is specifically designated to regulating cell proliferation, cell differentiation, and apoptosis among other additional functions involving the nervous system. Examples…

the Cell Cycle is a series of events that take place in a cell leading to its division and duplication of its DNA. If the cell is not corrected by additional effective system it can lead to Apoptosis (Programmed Cell-death), which is one of the natural cell-death. The types of natural deaths include apoptosis, necrosis and mitotic catastrophe. If abnormal cells are not corrected and Natural cell death does not occur, they result to the development of a tumor that is then formed by the…

infarcts. Finally, the severe prolonged ischemia (without necrosis) can cause myocyte vacuolization (often termed myocytolysis), hydropic, vascular, and fatty degeneration. Apoptosis (programmed cell death) is an additional pathway of myocyte death after ischaemia. In contrast to coagulation necrosis, myocytes undergoing apoptosis exhibit shrinkage of cells, fragmentation of DNA, and phagocytosis [7,…

transduction into monocytes, granulocytes, and lymphocytes using various chemical agents (Cirtain et al., 2016). HL-60 cells are also used to test differentiation by viewing the cell morphology and apoptosis. After differentiation, HL-60 cells are no longer immortal and undergo an apoptosis. Apoptosis is a naturally occurring programmed cell death (Cirtain et al.,…

Bacillus anthracis is the causative organism of the serious infectious disease, called anthrax. There are three manifestations of this disease. The manifestations include gastrointestinal anthrax, inhalation anthrax, and cutaneous anthrax. This research will explore the morphology, virulence factors, reservoir, transmission, and portal of entry of B. anthracis. The pathogenesis will also be reviewed, including symptoms, how B. anthracis causes these symptoms, the possible complications of the…

Tooth agenesis - non formation of the tooth is the most common dental anomaly seen by a dental practitioner. The overall prevalence of this anomaly excluding 3rd molar is 6.4%. But the prevalence varies depending upon the continent – highest of 13.4% in Africa to the lower prevalence of 4.4% in Latin America and Carribbean and it is 1.22 times more prevalent in females1. Congenital missing teeth fewer than 6 teeth are known as hypodontia whereas absence of more than 6 teeth is called as…

TAZ gene, is a mitochondrial membrane-associated protein that remodels cardiolipin (CL), an important mitochondrial phospholipid. CL is essential for proper mitochondrial structure and function, ensuring proper functioning of energy production and apoptosis. TAZ mutations are associated with the X-linked metabolic disorder, Barth syndrome (BTHS). BTHS is a lipid metabolic disorder that affects mitochondria that is often fatal in infancy and early childhood, due to heart failure and life…

the details of the gene's involvement are still being researched. EHBP1 is primarily known as a marker for prostate cancer. EHBP1 is involved in the proper functioning of nuclear AKt, a protein kinase that is involved in apoptosis. A change in EHBP1 may cause issues with apoptosis, which can lead to a tumor. The type of cancer associated with defects or variations in the EHBP1 gene is prostate cancer. The type of prostate cancer is called, "Prostate Cancer, Hereditary, 12." EHBP1 is associated…

knocked out there is no regulation of proliferation, mutations of TP53, a tumor suppressor gene, occurs in only 3% of patients that have ALL (Gallegos-Arreola et al., 2013). A third hallmark is evading apoptosis; types of genes common to be knocked out are from the NOTCH family, since they inhibit apoptosis stimulated by p53 allowing the tumor to worsen,” (Gallegos-Arreola et al., 2013). The fourth hallmark is limitless replication, meaning nothing can stop the growth of the tumor (Huether &…

The enrichment of Role of Deleted in Colorectal Carcinoma (DCC) in regulating apoptosis signal transduction pathway was an important finding that indicated the role of Dapk1 in colorectal carcinoma through regulation of ligand-independent caspase activation (Forcet, et al., 2001). The pathways related to Notch signaling were the next…