Apoptosis

Division of pre-existing cells is the only way through which new cells can come into being. For duplication of cells to happen, the genetic materials inside the cells have to duplicate first. During the S phase of the cell cycle, the chromosomes of the cells as well as the chromatin proteins duplicate. During the M phase, spindle fibers are formed, and the duplicated chromosomes arrange themselves in the equatorial region of the cells forming a metaphase plate. Mitotic spindles are formed by the…

Km and Vmax determination of glucocerebrosidase towards p-NPG The Michaelis constant (Km) is a measure of the affinity of the enzyme towards the substrate, with smaller values representing greater affinity. Km and the maximum rate (Vmax) of leukocyte GCase were obtained through the Lineweaver-Burk plot (Figure 4) with artificial substrate p-NPG in concentrations from 0.71 mM to2.50 mM. Km and Vmax values for leukocyte GCase using p-NPG as substrate was found to be 12.6 mM and 333 U/mg…

Sirtuins and Histone deactylases (HDACs) Eukaryotic DNA is packed in a high level structure called chromatin, resulting from the assembly of an elementary unit, the nucleosome, and an octameric structure obtained from eight proteins called histones [1]. Histone deacetylation is a reversible process whereby histone and non-histone protein transfer the acetyl moiety from acetyl co-enzyme A (CoA) to lysines while histone acetylation is the direct opposite process whereby acetyl groups are removed…

MYCOCEPT (Mycophenolate mofetil) is the 2-morholinoethyl ester of mycophenolic acid (MPA). CHEMICAL NAME: 2-morpholin-4-ylethyl (E)-6- (4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4 enoate. STRUCTURAL FORMULA: Fig: Mycophenolate mofetil MOLECULAR WEIGHT: 433.50g/mol APPEARANCE: Mycophenolate mofetil, is a white to off-white crystalline powder. SOLUBILITY: It is slightly…

BRCA1 and BRCA2 genetic testing, should everyone do it? Introduction Cancer happens when the cells in the body grow out of control and make tumors. This procedure is organized by biochemical in different parts of the body. (7) Breast cancer is the most common cancer among all the woman and about 5-10 percent of breast cancers are heritable. (9) Mutation in BRCA genes is responsible for 25 percent Inherent Breast cancer. Breast cancer is affected by so many risk factors. Every year about 233,000…

of the Lemurian order is to reestablish an age of peace akin to the first golden age in which all creatures can coexist. Humanity is sick and dying. By breeding a new race, we could improve our species. They would be stronger, healthier, smarter and possess an improved longevity. Just imagine never looking a day over twenty five. " "The watcher’s DNA is the key to immortality." A scientist commented. “How so?” "I am Dr. Crenshaw by the way, and by examining the Nephilim, it is far easier to…

PHYTOCHEMICAL SCREENING AND ANTICONVULSANT ACTIVITY OF CITRUS GRANDIS LEAF EXTRACT IN EXPERIMENTAL MICE Dasarapu Santhosha *, Alluri Ramesh Vishnu Institute of Pharmaceutical Education and Research, Narsapur, Medak, Telangana ABSTRACT In the present study , antiepileptic effect of the methanolic extract of the leaves of Citrus Grandis was evaluated by hand limb extension induced by chemically induced seizures in mice models.Two different doses were selected .The methanol extract of the…

calcitonin-salmon sprays. Bisphosphonates are equivalent to pyrophosphates, which have a strong liking towards bone apatite. They mediate the stoppage of bone resorption by lowering the recruitment and functionality of osteoclasts. Cell death or apoptosis is also induced within the osteoclasts, leading to the eventual decrease in number of osteoclasts. Another useful drug therapy that works in a similar manner is salmon calcitonin. There is FDA approval for the use of this drug through an…

Currently, Dr. Rong Lu conducts research at the University of Southern California (USC). Her lab investigates stem cell malfunction, regulation, and coordination at the single cell level (1). Furthermore, she uses mouse hematopoietic stem cells (HSCs) as a model system (1). Dr. Lu’s research utilize various disciplines of biology such as molecular, cellular, and systems biology (1). Additionally, Dr. Lu’s research focuses on investigating the differences and coordination between individual stem…

BRCA1 and BRCA2 genetic testing, should everyone do it? Shahrzad Eslamian Purpose: For a person with a positive mutation in BRCA1 or BRCA2, the chance of getting breast cancer increases by 50-60 percent.1 This causes concern for some women and makes them take a BRCA1/2 mutation test to make sure they are not carrying this mutation. In September 2015, a research from UCLA was published that indicated some debate over whether or not testing BRCA genes is worth the cost.4 This paper will be…