Apoptosis

Introduction Vincrestine is a plant alkaloid, obtained from the Madagascar periwinkle cathanthus roeus. Before it was used for cancer treatment, the natives of Madagascar used it for the treatment of diabetes and high blood pressure. Structure of Vincrestine: Vincristine has two monomer alkaloid parts, catharanthrine and vindoline, with a formyl group on the indole nitrogen of the vindoline skeleton. Formula C46H56N4O10 Disease it Targets: Vincristine is used to treat various types of cancer.…

INTRODUCTION Cancer can be defined as a special kind of illness that occurs when the cells in a given part of a body begin to grow out of proportion than is normal. Currently, in the United States, this disease is the second leading cause of deaths. Human beings over the history have had tumors and remedies have been implemented, and others continue to be performed and studied over time (American Cancer Society, 2010). These methods of treatment include chemo-preventive methods and of late…

Chemistry: Enasidenib is a first in class, a selective allosteric inhibitor of mutant isocitrate dehydrogenase-2 (IDH2) inhibitor discovered at Agios Pharmaceutical, Inc. in the United States of America. Recently, on 1 August 2017, Celgene Corporation and Agios Pharmaceutical in cooperation won the approval for Enasidenib under brand name IdhifaTm for the treatment of relapsed/refractory acute myeloid leukemia. it is a white to off-white crystalline, non hygroscopic powder existing in…

The maintenance of skeletal muscle mass and metabolic capacity is extremely important for human health and quality of life (Wolfe RR 2006). Skeletal muscle has distinct metabolic and contractile properties that can be influenced by nutrients uptake, microenvironment, and contractile activity. Plasticity and heterogeneity have also been shown to be hallmarks of skeletal muscle as shown by muscle morphology, fiber type, and oxidative capacity. Age, disuse, fasting and various degenerative diseases…

Comparing marijuana smoking to tobacco smoking seems like an easy answer, tobacco is bad end of story. This is true, but isn’t smoking marijuana also harmful to the lungs and pulmonary system? There have been studies that have concluded smoking marijuana does not do the same damage as tobacco. This statement is somewhat misleading because marijuana smoking has not yet been found to be a factor in causing cancer; however, cannabis has been linked to respiratory issues such as bronchitis and…

Anti-Calbindin binds to Calbindin (CB) and labels GABAergic neurons In our immunohistochemistry (IHC) experiment, we used anti-Calbindin as our primary antibody, Goat anti-Rabbit 488 IgG as our secondary antibody (“488” meaning that the fluorescent dye is excited at a wavelength of 488nm, fluorescing green), and DAPI-mounting serum as a DNA (nucleus) marker with blue fluorescence for reference against anti-Calbindin-marked GABAergic neurons (Lammel, 2016). While GABAergic-neuron-expressing…

Cancer is a serious cause of death globally. Cancerous cells cannot be distinguished easily from the normal cells. Rapid development of cancerous cells depends on the process of Angiogenesis. Inhibition of the angiogenesis is a novel strategy in cancer treatment. Currently, herbal medicines are also being used, along with chemotherapy to reduce the side effects. For the present study, Neem was selected as it is a versatile tree in India. From the ancient times it has been considered as a mighty…

Cancer has a major impact on society in the United States and across America. In 2016 an estimated 1,685,210 new cases of cancer will be diagnosed in the United States and 595,690 will die from the disease. The most common cancers in 2016 are projected to be Breast Cancer, lung and bronchus cancer, prostate cancer, colon and rectum cancer, bladder cancer, melanoma of the skin, non-Hodgkin lymphoma, thyroid cancer, kidney and renal pelvis cancer, leukemia, endometrial cancer, and pancreatic…

principle. According to goal standards, the DNAse destroyed the DNA of the ampicillin resistant strain of which the recombination of dna could not occur and the e. coli was still ampicillin sensitive thus when exposed to the agar plate it led to direct apoptosis as the genome had no gene for ampicillin. Therefore, the goal standards approves the evidence of the last 60…

The dry dead leafs crush beneath ones feet and a world away the loving breeze cools the mystical forest. Each individual experiences nature in my different ways, wither there is hail or sunshine. Our world, however, has lost some of its beauty and some feel that an assault on our home soil is necessary to survival. There is indeed no doubt that man has changed the forces of the earth, yet it is for the better for the human race; or so one may think. Edward O. Wilson felt the crisp dry dead…