Apoptosis

Parthenolide and STAT: It is previously discussed that the activation of STAT directs to cell proliferation, cell migration, transformation, apoptosis, cellular differentiation, adhesion, fetal development, inflammation, and immune response. In normal homeostasis, STAT tyrosine phosphorylation is short-term, lasting from 30 minutes to several hours, where as in numerous cancer cell lines and primary tumors it is in contrary to that of normal homeostasis. It takes place due to the deregulation of…

Immunology Journal Article 2 Answers 1. The phenomenon of clonal selection and expansion occurs when T and B cells are activated by an invading pathogen. The leukocytes that have specific receptors for the pathogen are selected for and begin to divide via mitosis. The large number of cells that result from this expansion all have the same receptor for the pathogen that first activated the cells. Since these cells are specific for that pathogen, they are able to fight off the infection caused by…

This article (Thymoquinone, Constituents of Nigella Sativa, on Human Cancer Cell Lines) states that thymoquinone destroys cancer cells by inducing apoptosis. The scientists of the article investigated the effect of thymoquinone on lung carcinoma, larynx epidermoid carcinoma, colon adenocarcinoma, and pancreatic carcinoma. Thymoquinone was found to have both cytotoxic and apoptotic effects on the cancers…

(scientific words) in your own words. (notes or textbook can be used as sources) Ricin toxin A (RTA) → toxic protein from seeds of castor plants. Subunit A depurinates adenine in cells Mutants → The process of a gene or chromosome being altered Apoptosis → cell suicide Cell signaling → oversees cellular activities and directs cell actions Signal transduction → Process where a signal from outside of the cell changes something within the cell Ribosome depurination → In N-glycosidic link…

1.INTRODUCTION p53, also known as TP53 or tumor protein, is a gene that codes for one protein which stimulates another protein that inhibits enzymes needed to drive the cell cycle and functions as a tumor suppression. It is very important for cells in the role to suppress cancer. P53 has been described as "the guardian of the genome", referring to its role in conserving stability by preventing genome mutation (Strachan and Read, 1999). The name is due to its molecular…

mechanisms compared to other mammals. Mammals typically have several methods, such as inducing apoptosis, releasing cyclin-dependent kinase inhibitors (bound to CDK complexes) which signal cells to stop within a stage of the cell cycle, and contact inhibition in which cells stop growing once they make contact with each other. These mole rats’ distinct mechanisms modify contact inhibition and apoptosis to achieve the mole rats’ cancer resistance and longevity (Seluanov, et.al., 2009; Gorbunova,…

studies supports a causal relationship between intravenous and inhaled anesthetic exposure and brain development, triggering increased apoptosis, with negative neurocognitive and behavioral outcomes. • All these negative events take place during a high vulnerability period on brain development known as “brain spurt”. • Normally, 70% of neurons will undergo apoptosis during brain development. Gamma aminobutyric acid (GABA) and glutamate receptor modulation may be involved in apoptotic pathway…

newly approved drugs by the FDA. Chidamide acts to inhibit the growth of tumor cells by epigenetic regulation of HDACs, causing the regulation of the cell cycle and even apoptosis for patients with pancreatic cancer. Panobinostat, similarly, can act to arrest the cell cycle and also cause caspase dependent and independent apoptosis in patients with multiple…

Cancer is a deadly disease where one of the only treatments we have is chemotherapy. But what is the cause of cancer? There are many environmental factors that can play a role in the diagnosis of cancer. Obesity, age, viruses, genetic mutations, and various carcinogens can cause cancer. However, what is happening at the cellular level when cancer metastasizes throughout the body? There are many different known causes, but most of them revolve around the cells ability to stop proliferating and…

growth, differentiation, migration, apoptosis and cell connections. Cell division is a cell progressing through the cell cycle in order to multiply. Cell growth is a cell using the nutrient and optimal environment to grow in volume. Differentiation is a cell turning into specialized cells due to different gene regulators. Migration is a cell moving to the appropriate position within the body, it also is used to fix parts of the body when they are damaged. Apoptosis is cell death that is…