Apoptosis

very good cytotoxic agents against different types of cancer cell lines. 8 Recently bisbenzimidazole conjugates have been reported to target mitochondria in cancer cells and induce their antiproliferative activity by caspase 2,3 Most dependent apoptosis. 9 50…

Infiltration of macrophages is commonly observed in both forms of advanced AMD. Activated macrophages can induce death of RPE by activation of the complement cascade or induce apoptosis by a contact dependent mechanism [14, 15]. Based on functions, cytokine profiles, and surface markers, macrophages can be classified as M1 (pro-inflammatory) and M2 macrophages (pro-angiogenic). These two types of macrophages carry out distinct biological…

effects of cation binding on protein interactions as well as research on protein misfolding.1 α-Lactalbumin gives milk an antimicrobial property, making it important for infant health, and recently, studies have shown that α-lactalbumin can trigger apoptosis in tumor cells.1,2 In order for the functions of α-lactalbumin to be researched further, it must be effectively isolated from milk. This lab separated α-lactalbumin from other milk…

acting as a chain-breaking antioxidant (Reason et al., 2011). It suppresses the activation of NF ƙB, an inducible transcription factor that regulates expression of anti-apoptotic genes and induces metastasis (Garg and Aggarwal, 2002) thus increases apoptosis as observed in the current…

By Shamik D. Majumdar What does cancer cell mean? Normal cells can repair themselves if any part gets damaged . This process is known as DNA repair. If the damage is too bad, they will self slaughter- known as apoptosis. (1) The molecules in cancer cells decide whether a cell should repair itself or not .EX: “a protein called p53 normally checks to see if the genes can be repaired or whether the cell should die”, so basically it decides to repair itself. But many…

The cancer cells under stress use EMT phenomenon as cell survival mechanism to escape apoptosis, anoikis and general immune response. Autophagy triggered in response to stress conditions like starvation, is also used by cancerous cells for survival by recycling of cellular components. There is a cross talk between pathways involved in EMT and autophagy. The involvement of TGF-β signalling pathway had been observed induction of EMT and autophagy in many cell types. Autophagy is a context…

allows it to invade normal brain tissue. The cancer is highly malignant and is proto-oncogene. It’s characterized by uncontrolled cellular proliferation, diffuse infiltration, tendency for necrosis, significant angiogenesis, intense resistance to apoptosis, and widespread genomic aberrations. The tumor arises from the astrocytes which are star shaped cells that make up the brains supportive tissue. As a result of the cancer spreading through the brain tissue so quickly, most people who get this…

List the hormones that play a role in the urinary system and what they do. Vasopressin (ADH antidiuretic hormone) and aldosterone are the hormones that play a role in the urinary system. In the urinary system vasopressin regulates water loss and aldosterone maintains the balance of electrolytes and water. Sources: "Vasopressin | Definition of Vasopressin by Medical Dictionary." TheFreeDictionary.com. N.p., n.d. Web. 19 Dec. 2015. . "Aldosterone | Definition of Aldosterone by…

1. Hypothesis Statements We are testing the efficiency of an in vivo tool for screening the effects of anti-cancer drugs on zebrafish embryos and comparing the results and their cytotoxicity with MTT assay of the MCF7 breast cancer cell line. The results will indicate if the drugs have similar effects on both breast cancer cells and zebrafish embryos. It is given that embryogenesis and carcinogenesis have similar molecular mechanisms, therefore it is expected that these cell types act somewhat…

The hippocampus structure is most associated with how one's mental processes respond and adjust to a physical stimuli through learning and behavior (Curlik & Shors, 2013, p. 506). 3. Although most of the new cells die by programmed cell death (apoptosis), the researchers describe that some can be rescued. How does this rescuing occur? Curlik and Shors (2013) found that experiences from a past situations are then applied to future experiences causing an increase in competency and skill, this…