Amide

3396.46 0.9280 Medium N-H stretch Amides, alcohols and amines 5 2987.43 0.2450 Medium C-H stretch Alkanes and acids 6 2946.27 0.2810 Medium C-H stretch Alkanes and acids 7 2912.38 0.2040 Medium C-H stretch Alkanes 8 2834.49 0.3170 Weak C-H stretch Aldehydes and acids 9 2524.07 0.0337 Medium O-H stretch Carboxylic acids 10 2226.40 0.0033 Weak C ≡C stretch Alkynes 11 2043.60 0.0059 Unknown 12 1785.35 0.0104 Unknown 13 1659.54 0.0303 Medium C =C stretch Amides and alkenes 14 1477.37 0.0519…

Chapter Three - Conclusions 3.1 Conclusions This research aimed to verify the synthesis protocol for HPA-12 and analogues from aldehydes of Greatrex et al. (2014). Limited success in synthesising required quantities had a negative impact on the outcomes of this research, and no reasons were identified for the low yields that were obtained. Additional time, or resolution of issues resulting in low yields, would have allowed additional research and confirmation of the synthesis protocol. Long…

benzocaine beginning from vasicine with is found in the leaves of Adhatoda vasica. Specifically, nitro compounds were mixed with vascine in 120°C water for 24 hours and then purified by column chromatography. The final step involved the replacement of an amide with an amine. The result was a 66% yield of benzocaine which is significantly higher than the typical yield of the synthesis of benzocaine from p-toluidine as performed in this experiment. Ding and Chang-Ze describe the synthesis of…

Lidocaine: Introduction: Thesis: Lidocaine is a widely used local anesthetic that can be used in many types of conditions, however the focus will be on the local anesthetic administration in dental procedures. 1. Structural information and chemical properties: (National Center) a. Chemical name and trade name: 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide, Lidocaine b. Chemical structure: (Figure 1: Lidocaine Structure) c. Molecular formula: C14H22N2O d. Molecular weight: 234.343 g/mol e.…

nucleophilicity in the DNA-catalyzed amide bond cleavage reaction. I worked closely with my graduate mentor and advisor in the design of the selection experiments. Also, I prepared nucleopeptide and oligonucleotide substrates, and performed the selection experiments. New DNA catalysts were not found, suggesting that 40-nucleotide-long DNA sequences do not have the capability to catalyze amide cleavage even with stronger nucleophiles and more electrophilic amide…

have been widely investigated for applications in different field due to its low toxicity, biocompatibility and good film forming (Hemalatha et al. 2014; Anasuya; Lee et al. 2007). The amide group in NVP is highly polar, which confirms it’s hydrophilic. NVP has been copolymerized with various monomers because the amide group has high affinity for many large and small molecules that are known to be good hydrogen-bond acceptors (Jin et al. 2013; Santanakrishnan et al. 2012; Arosio et al. 2011).…

IDENTIFICATION & CRYSTAL STRUSTURE ANALYSIS OF ISONICOTINAMIDE POLYMORPHS. INTRODUCTION The science of crystallography is important in stability studies and determination of solid state molecule or particles. Isonicotinamide (pyridine -4- carboxamide) is the amide form of isonicotinic acid which exists as different polymorphs. Isonicotinamide finds extensive use in the pharmaceutical industry because of its good anti-tubercular, anti-bacterial, anti-pyretic and fibrinolytic properties (Li et…

of the DD-transpeptidase occurs due to the nucleophilic attack of the carbonyl on the β-lactam ring by the serine hydroxyl group in the enzyme active site, thus producing a stable acyl-enzyme complex. The tetrahedral structure is then broken at the amide bond, allowing the nitrogen within the ring to be reduced. Scheme 2: β-lactam antibiotic mechanism with DD-transpeptidase STAND IN. Therefore, the covalent bond between the β-lactam antibiotic and the DD-transpeptidase prevents the…

Proteins Molecules Building materials for cells. Cells have organelles such as mitochondria, lysosomes, vesicles, etc. It is estimated that the body has over ten trillions cells Carry oxygen, build tissue, copy DNA for the next generation and do the work needed by the body. Deoxyribonucleic acid contains the blueprint for proteins and replication of itself mRNA transcribes DNA, tRNA translates mRNA into proteins. A pattern on nucleotide on a DNA strand is called a gene. The Central Dogma of…

CHAPTER 1 INTRODUCTION 1.1. Introduction Caprolactam (CPL) is an organic compound with the formula (CH2)5C(O)NH. This colourless solid is a lactam or a cyclic amide of caproic acid. Caprolactam was first described in the late 1800s by Gabriel and Mass, when it was prepared by the cyclization of ε-aminocaproic acid, the product of the hydrolysis of caprolactam. In the months after Schlack’s discovery the first stocking were produced from Perlon. All the Perlon produced went to the war effort.…