Allele

One important allele is the S beta chain responsible for sickle cell anemia, it differs in one amino acid from a normal beta-chain. At the beta gene locus, two possible alleles have two base sequences A = normal beta-chain and S = sickle-cell beta chain. Sickle cell anemia is due to abnormality of hemoglobin, a (protein carrying oxygen to the tissues). “Anemia is a decrease in RBCs; or hemoglobin; or ability to carry oxygen. Hemoglobin S (allele HbS) causes Sickle Cell Anemia, without…

In addition, nations with the lowest presence of this allele are less likely to rate themselves as ‘very happy’, these nations include Iraq, Jordan, and more. However, the researchers also note that economic and political factors may affect the low happiness scores in some nations, despite high presence of the allele (“Happy Nations Can Thank Their Genes” 2016). While the positive correlation between the presence of the allele and a nation’s happiness does not cause the nation to be happy…

“If you know you are on the right track, if you have this inner knowledge, then no body can turn you off… And no matter what they say.” “It might seem unfair to reward a person for having so much pleasure over the years, asking the maize plant to solve specific problems and then watching its responses.” [https://www.brainyquote.com/quotes/authors/b/barbara_mcclintock.html] Barbara McClintock wrote these quotes, above. Barbara was the American scientist, who discovered “Mobile Genetic Elements”…

many deleterious recessive alleles, and possibly caused the population to decline. The Isle Royale wolves selected against the progeny of M93 due to their high frequencies of deleterious alleles and high inbreeding coefficients even though the progeny had high heterozygosity. The Isle Royale wolves similar to the Chillingham cattle learnt in class, have appeared to evolve to exist with low heterozygosity levels in the population by purging deleterious recessive alleles over time and thus,…

The experiments covered in this report are based on the topic of DNA polymorphisms, these according to Houseman (1995) are differences in the DNA that occur between individuals. The polymorphisms under investigation here are classified as VNTR’s (variable number tandem repeats) and RFLP’s (restriction fragment length polymorphism). The first experiment is concerned with DNA polymorphisms that are known as VNTR’s, sections of DNA which have repeated nucleotide base sections in which the repeats…

Hyperthyroidism is due a mutation occurring in the gene that encodes the functions of your thyroid. This disease prevents the thyroid from producing specific hormones, but also causes iodine deficiency and an error in the metabolic process. I carry two alleles for this mutation; meaning that I had inherited the mutation from both parents. Treating this disease is vital as it usually begins to negatively affect the body early on (great consequences are implied if not treated). Some of the…

Poor metabolizer Two inactive alleles Standard dose. Dose increase probably not necessary; be alert to adverse drug events. Atomoxetine is primarily metabolized through the CYP2D6 enzymatic pathway. The main metabolite, 4-hydroxyatomoxetine, is equipotent to atomoxetine as an inhibitor…

Cystic fibrosis is recessive meaning that both parents must have at least one cystic fibrosis allele. Another autosomal disease is called Huntington Disease. This is a degenerative disease that degrades the nervous system and leads to the breakdown of nerve cells in the brain. This leads to mental deterioration and eventually death. Huntington disease…

conservation biologists no longer have control over who mates with who, the ferrets would have a more diversified gene pool for their random mating. Therefore, there would be less of a chance that certain alleles would be lost prematurely or so soon after their release. To further the importance of having high allele counts in the ferret population upon release, a study on the mortality of Siberian polecats and black-footed ferrets released onto prairie dog colonies was done and according to it,…

Davenport & Davenport (1909) had reported many examples of 2 brown-hair parents with red-hair offspring’s which could suggest it is because of recessive alleles, but Neel (1943) established 13 in 114 offspring’s of 2 red-hair parents had non-red hair. Reed (1952) reviewed various hypotheses which have been proposed. Valverde et al. (1995) made a survey of DNA sequence variations. Beaumont and others in 2007…