Beta blockers are the first line drug choice when treating angina related to CAD. Beta blockers decrease cardiac oxygen demand, by blocking beta receptors in the heart, decreasing heart rate and contractibility, reducing peripheral resistance and after load. Slowing heart rate increases diastolic fill time, increasing the amount of time blood flows throughout myocardial vessels. When taken with nitroglycerin, extra benefits include blunting reflex tachycardia. Dosage starts out low and slowly…
angiotensin to angiotensin II (AII). AII increases systemic vascular resistance (SVR) and arterial pressure, and stimulates the release of aldosterone causing sodium reabsorption and water retention in the body (Klabunde, 2014). As sodium and fluid retention occurs, preload increases CO thus increasing blood pressure and renal perfusion (Andrew, 2002). AII and aldosterone lead to cardiac muscle apoptosis resulting in fibroblast activation, myocardial scarring and cardiac remodelling, causing…
pressure, the volume of blood, and the fluid and electrolyte balance in the body. Angiotensin II controls vasoconstriction in the circulatory system, which increases blood pressure and can cause hypertension (Burchum and Rosenthal, 2016,p.471-473). Aldosterone is what controls the fluid and electrolyte balance in the body. It also is released from the adrenal cortex and activates retention of sodium, which increases the fluid volume, which consequently increases the blood pressure (Dhillon S.,…
Glomerular filtration is the physical method the kidney uses to sort what should be excreted from what should be kept in the bloodstream. In the first part of the process, a membrane called the filtrate membrane filters out red blood cells, large proteins, and other large plasma solutes. For example, albumin is filtered out at this point, with only a tiny amount remaining in the subsequent glomerular filtrate. Because the afferent arteriole to the glomerulus is much larger than its efferent…
Extra if needed Diagnosis of PAI initially involves blood assay for elevated ACTH and plasma renin activity (PRA) with decreased serum cortisol and aldosterone, DHEAS [1, 2]. Exclusion of other autoimmune conditions and imaging of the adrenal glands completes diagnostic testing and results [3]. Diagnostic Testing and Results Optimal levels of serum cortisol and plasma ACTH are simultaneously measured early morning between 8-9am, in healthy individuals the serum cortisol levels can range…
mechanism is the renin-angiotensin-aldosterone mechanism. If the kidneys sense that they are not receiving enough blood, they will release renin which is converted to angiotensin I by angiotensinogen and then angiotensin II an enzyme. Angiotensin II is a potent vasoconstrictor that will allow for an increase in preload, which will then increase contractility and an eventual increase in stroke volume and CO consequently; it will also lead to an increase in aldosterone that will help to increase…
This lab included various experiments that demonstrated how renal system responses and reacts when subjects consuming different types of fluids. Respective fluid volumes are based on each subject’s body mass. Based on each subject’s body mass, after converted from pounds to kilograms, every subjects has different volume and fluids for ingestion. For the control subject, she ingested no fluid throughout entire lab which represented the conditions of normal fluid. For the hypotonic subjects, she…
fight-or-flight response A) is the body’s immediate response to a real or perceived threat to survival. B) elevates heart and respiration rates and blood glucose level. C) decreases urinary and digestive functions. D) activates the renin-angiotensin-aldosterone pathway. E) All of these are correct. ____ 80. The resistance stage of the stress response A) precedes the fight-or-flight response. B) is mediated primarily by CRH, GHRH, and TRH. C) is briefer than the fight-or-flight response. D)…
with extreme physical stress, an injury, or during birth. It also helps the body regulate the metabolism and maintain blood pressure. Another hormone that sometimes the adrenals do not make is aldosterone. This hormone helps the body retain salt needs and keeps your blood pressure steady. When aldosterone levels drops, the kidneys cannot keep the salt and water levels in balance. Because of this,…
The glomerular filtration rate (GFR) filters the plasma through the glomerulus capillary blood pressure and into the Bowman’s capsule hydrostatic pressure (Sherwood, 2007, pp. 508-509). The filtrate subsequently travels into the proximal tubular so that sodium absorption occurs. The tubular reabsorption is the filtrate that flows through the tubules and the substances of value returns to the perutubular capillary plasma into the blood stream (Sherwood, 2007, p. 506). Such that the body can…