AKT

• Treatment There are a wide variety of therapeutics options for lymphomas and the election of them is based on the type of lymphoma, the progression of the disease, characteristics of each patient… However, the 3 main therapeutic options are chemotherapy, radiotherapy and immunotherapy. In this part, these and other methods will be analysed. Surgery Surgery has not any relevant role in the treatment of lymphomas13, it just have a role on the diagnosis (obtaining of biopsy material) and…

Legalization of medical cannabis remains a controversial topic throughout the western world. Despite a lack of clarity as to the long term effects of cannabis, over two-thirds of the 1,500 doctors involved in a U.S. nationwide survey support the provision of medical marijuana as an option for patients, having frequently been cited in various clinical studies as a potent analgesic and anti-epileptic (WebMD, 2014). The Misuse of Drugs Regulations 2001 classifies cannabis as a schedule I drug in…

Discussion The mechanism of arsenic-induced neurotoxicity is not well defined. Several metabolites of arsenic are able to pass through the blood-brain barrier and accumulate in the hippocampus and some other locations [13]. This affects the intracellular Ca(2+) homeostasis and ultrastructures of hippocampal neurons. In relation to the amino acid neurotransmission, report reveal that arsenic-induced excessive glutamate accumulation in the extracellular space induces excitotoxicity [29]. Arsenic…

Alzheimer’s disease affects more than 15 million individuals worldwide from mild to severe. (Lilienfeld, 2006). It is a progressive and irreversible disease that leads to full dependency on a caretaker due to the decline in cognitive function and ability to perform daily tasks (Richarz, Gaudig, Rettig, & Schauble, 2014). Alzheimer’s disease is the most common form of dementia and normally occurs within individuals 60 years of age or older (Lilienfeld, 2006). Every twenty years the number of…

Cancer represents a heterogeneous group of diseases. It is characterized by uncontrolled cell growth and a collapse of all multicellular co-operations (Zhang, et al., 2016; Zhang and Sun, 2015; Zhong, et al., 2016). Cancer promotes tumor development and metastasis (Ahmed, et al., 2013; Zhu, et al., 2016). Tumors are characterized by six essential alterations in cell physiology. These are self-sufficiency in growth signals, continued angiogenesis, insensitivity to growth inhibition signals,…

Bertelson, A., (1989). A confirming unexpressed genotype for schizophrenia. Archives of General Psychiatry, 46,867-872. Kim, J. Y., Duian, X., Liu, C. Y., et al. (2009). DISC1 regulates new neuron development in the Adult brain via modulation of AKT-mTOR signaling through KIAA1212. Neuron, 63, 721-773. MacDonald, A. W., Carter, C. S., Kerns, J. G., Ursu, S., et al (2005). Specificity of the prefrontal dysfunction and context processing deficits to schizophrenia n never-medicated patients…

Kaempferol is a natural polyphenol, secondary metabolite (flavonol), a type of flavonoid, found in a variety of plant-derived foods. Kaempferol is a yellow crystalline solid with a melting point of 276–278 °C. It is slightly soluble in water and highly soluble in hot ethanol, ethers, and DMSO. Kaempferol acts as an antioxidant by reducing oxidative stress. Many studies suggest that consuming kaempferol may reduce the risk of various cancers, and it is currently under consideration as a possible…

for Neuroprotective Therapy. Pharmacology. 2009; 3: 411-416. David C. Henshall, Tomohiro Araki, Clara K. Schindler, Jing-Quan Lan, Kenneth L. Tiekoter, Waro Taki, and Roger P. Simon. Activation of Bcl-2-Associated Death Protein and CounterResponse of Akt within Cell Populations during Seizure-Induced Neuronal Death. The Journal of Neuroscience. 2002;22(19):8458?8465. Komaki S, Kohno M, Matsuura N, Shimadzu M, Adachi N, Hoshide R, Nishiyama S, Matsuda I. The polymorphic 43Thr BCL-2 protein…