Alcohol Essay

1-[Cyano(4-methoxyphenyl)methyl]cycloalkanol (VF-I) synthesized through the reaction of p-methoxyphenylacetonitrile and cyclohexanone using aq. NaOH and tetrabutylammonium hydrogen sulfate as PTC. NaBH4 and CoCl2 in 2:1 THF: H2O used for the reduction of VF-I to obtain 1-(2-amino-1-(4-methoxyphenyl)ethyl)cyclohexanol (VF-II). Further, venlafaxine derivative of the amino acid -carboxamide (VFCA-I toVII ) synthesized through coupling of N-Phthaloyl amino acid chloride derivative (2a-2g-…

INTRODUCTION Background The macrocyclic organic molecules Phthalocyanines (1) which are comparable to the naturally occurring porphyrin (2) ring systems shown in (Figure 1). The porphyrin molecule consists up of four pyrrole subunits which are associated in n-conjugation by methine carbons. 1 2 Figure 1: structures of phthalocyanine and porphyrins molcule The compound…

The role of oxysterols in human body and disease 1. Introduction Oxysterols are 27-carbon derivatives of cholesterol created by spontaneous or enzymatic oxidation (Figure 1, (Brown and Jessup, 2009)). The oxidation of cholesterol occurs either on the side chain or on the sterol core. Side chain oxidation generates, e.g., 24-hydroxycholesterol (24-HC), 25-hydroxycholesterol (25-HC) or 27-hydroxycholesterol (27-HC) while the core oxidation gives rise to ring oxysterols, mostly ring-B oxysterols,…

The goal of this lab was to conduct the reaction of 2-methyl-2-butanol with HCl to form 2-chloro-2-methylbutane, and to understand Sn1 and Sn2 reactions, in terms of how they are different and why one is more likely to happen over the other. The OH group in 2-methl-2-butanol is attached to a tertiary Carbon, meaning the reaction should occur via Sn1, a two-step reaction, and Cl should replace the OH group, to form a tertiary halide. HCl was added to 2-methyl-2-butanol and then several…

Synthesis of reactive iron Chemical reduction method of Ferric chloride by sodium borohydride following reaction (Eq.1), was used to synthesize ZVI [14]. 〖2FeCl〗_3+〖6NaBH〗_4+〖18H〗_2 O→〖2Fe〗^0+〖21H〗_2+〖6B(OH)〗_3+6NaCl (1) Ferric chloride hexahydrate solution was prepared by dissolving 5 g of FeCl_3.H_2 O (99.0%, Junsei Chemical Co., Japan) in 125 mL of deoxygenated deionized (DI) water. Moreover, 3.5 g of Sodium borohydride (NaBH_4, 98.0%, Sigma–Aldrich Inc., USA) were dissolved in 125 mL…

The heterocyclic compounds naming tetrahydrocarbazoles having the significant biological properties. The newly substituted tetrahydrocarbazole derivatives were prepared from substituted phenylhydrazine and cyclohexanone in glacial acetic acid under reflux. These intermediates on reaction with substituted aromatic acid chlorides in alkaline media finally converted to N-Substituted tetrahydrocarbazoles. Fifteen compounds are synthesized and charaterized by their melting point (MP), IR, NMR, MS…

In this study, we use the modified organo nanoclay as a new sorbent for separation and preconcentration trace amounts of Au(III) in aqueous solutions. Nanoclay was modified with 5-(4'-dimethylamino benzyliden)-rhodanine. Modified nanoclay was used as a solid sorbent for separation and preconcentration trace amounts of Au(III) ions. The sorption of gold ions was quantitative in pH range of 2.0 to 6.0, whereas quantitative desorption occurs instantaneously with 6.0 mL of 1.0 mol L-1 Na2S2O3. The…

Soda is an addiction and all addictions have corruptive side-effects. Some side-effects of soda include irritability, restlessness, tension, insomnia, high blood pressure, gastrointestinal disturbance, excessive urination, irregular heartbeat, cell damage, dehydration, an impaired digestive system, liver problems, metabolic syndrome, accelerated aging, and cancer. Soda has toxic chemicals-brominated vegetable oil, or BVO, is an example. BVO is an industrial chemical used as a flame retardant in…

In the first step of the experiment, m-toluic acid reacted with thionyl chloride to form the acid chloride derivative of m-toluic acid. In this reaction, the carboxylic acid is first converted into an acyl chlorosulfite intermediate, replacing the –OH of the acid with a better leaving group. The acyl chlorosulfite then reacts with a nucleophilic chloride ion, at which point the chlorosulfite leaves in the form of sulfur dioxide and chloride ion. The remaining acid chloride then reacts with…

New research suggests that excess sugar, particularly the fructose in sugary drinks can potentially damage your brain. Researchers found that people who drink sugary beverages frequently often are more probable to have poorer memory, smaller brain size (volume), due to having a much smaller hippocampus, which is a part of the brain that is crucial for learning and memory. According to a follow-up study, it was found that people who drank diet soda daily were almost three times as likely to…