Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
46 Cards in this Set
- Front
- Back
cyclosporine mechanism
|
binds cyclophilins
they inhibit calcineurin --> preventing production of IL-2 and its receptor --> block differentiation and activation of T cells |
|
cyclosporine rx
|
organ rejection after transplantation
some autoimmune |
|
cyclosporine s/e's
|
viral infections
lymphoma nephrotoxic (prevent c. mannitol diuresis) |
|
tacrolimus is aka
|
FK506
|
|
FK506 is aka
|
tacrolimus
|
|
tacrolimus mechanism
|
binds FK-binding protein
--> inhibiting secretion of IL-2 |
|
tacrolimus rx
|
organ transplant pts
|
|
tacrolimus s/e's
|
nephrotoxicity
peripheral neuropathy pleural effusion hypertension hyperglycemia |
|
sirolimus is aka
|
rapamycin
|
|
rapamycin is aka
|
sirolimus
|
|
sirolimus moa
|
binds mTOR
inhibits T-cell proliferation in response to IL-2 |
|
sirolimus rx
|
immunosuppression after kidney transplantation
in combo with cyclosporine and corticosteroids |
|
sirolimus s/e's
|
hyperlipidemia
thrombocytopenia leukopenia |
|
daclizumab moa
|
antibody against IL-2 receptor
|
|
azathioprine moa
|
precursor of 6-MP
toxic to proliferating lymphocytes |
|
azathioprine rx
|
kidney transplantation
autoimmune disorders (including glomerulonephritis, hemolytic anemia) |
|
azathioprine s/e's
|
bone marrow suppression
toxicity is ^ by allopurinol |
|
muromonab-CD3 is aka
|
OKT3
|
|
OKT3 is aka
|
muromonab-CD3
|
|
muromonab moa
|
binds to CD3 (epsilon chain) on T cells
|
|
muromonab rx
|
kidney transplantation
|
|
drugs specifically listed for post kidney transplantation immunosuppression
|
sirolimus
azathioprine muromonab daclizumab |
|
muromonab s/e
|
cytokine release syndrome
hypersensitivity |
|
aldesleukin (IL-2)
|
renal cell carcinoma
metastatic melanoma |
|
a drug for renal cell carcinoma
& metastatic melanoma |
aldesleukin (IL-2)
|
|
recombinant
G-CSF GM-CSF |
filgrastim
sargramostim |
|
two drugs for recovery of bone marrow
|
filgrastim
sargramostim |
|
alpha-interferon
|
Hep B and C
Kaposi's leukemias melanoma |
|
beta-interferon
|
multiple sclerosis
|
|
gamma-interferon
|
chronic granulomatous disease
|
|
recombinant IL-11 is aka
|
oprelvekin
|
|
two drugs for thrombocytopenia
|
oprelvekin (IL-11)
thrombopoietin |
|
antibody against CD3
|
muromonab
|
|
antibody against IL-2
|
daclizumab
|
|
daclizumab rx
|
prevent acute rejection of renal transplant
|
|
antibodies against TNF-alpha
|
infliximab
adalimumab |
|
adalimumab is an Ab against
|
TNF-alpha
|
|
infliximab/adalimumab rx
|
infliximab: CRAP
Crohn's rheumatoid arthritis ankylosing spondylitis psoriatic arthritis adalimumab: CRP |
|
abciximab targets
|
glycoprotein IIb/IIIa
|
|
herceptin is aka
|
trastuzumab
|
|
abciximab rx (3)
|
--cardiac ischemia
--unstable angina --percutaneous coronary intervention |
|
trastuzumab targets
|
erb-B2
|
|
trastuzumab rx
|
Her-2 breast cancer
|
|
rituximab targets
|
CD20
|
|
what targets CD20?
|
rituximab
|
|
rituximab rx
|
B-cell non-Hodgkin's lymphoma
|