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8 Cards in this Set
- Front
- Back
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What are the conditions for a wound to heal by first intention? |
• This is seen in clean surgical incisions • The wound edges are apposed against each other • There is minimal tissue loss/ damage • There is no bacterial infection |
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What are the conditions for a wound to heal by second intention? |
• Loss of tissue is extensive (eg large wounds, extensive necrosis) • there is foreign material (debris from road traffic accidents ) • good apposition of wound edges is not possible • when there is severe infection in a wound |
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What does healing involve? |
Restoration of tissue architecture and funtion |
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Healing can occur in two ways. Describe. |
Healing can occur in two ways, they are:
•healing by regeneration : replacement of damaged tissue by proliferation of residual parenchymal cells
Scar tissue/ fibrosis: replacement of damaged tissue by scar formation which provides just enough stability for the injured tissue to function |
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Growth factors are regulated by ................. whose activity are controlled by .............. |
Cyclins, cyclin-dependent kinases |
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What are some growth factors in healing? What are their functions? |
Some growth factors in healing are:
•beta 1- found in bones, important for attracting macrophages and angiogenesis •bFGF - promotes neovascularisation •PDGF- found in platelets, monocytes, macrophages, endothelial cells |
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What are some growth factors in healing? What are their functions? |
Some growth factors in healing are:
•beta 1- found in bones, important for attracting macrophages and angiogenesis •bFGF - promotes neovascularisation •PDGF- found in platelets, monocytes, macrophages, endothelial cells |
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What are some growth factors in healing? What are their functions? |
Some growth factors in healing are:
•beta 1- found in bones, important for attracting macrophages and angiogenesis •bFGF - promotes neovascularisation •PDGF- found in platelets, monocytes, macrophages, endothelial cells |
