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10 Cards in this Set

  • Front
  • Back
Methotrexate inhibits cell division by blocking which phase of the normal cell cycle?
S phase of DNA synthesis
The anti-inflammatory affects of MTX are mediated by what?
Adenosine
What are the 2 FDA approved uses for MTX?
Psoriasis and Sezary Syndrome
Methotrexate is Pregnancy category what?
Pregnancy category X
What is the only absolute contraindication for MTX use?
Pregnancy
What organ is at risk with long-term use of MTX?
Liver
Pulmonary toxicity is a potential effect of what drug?
MTX
What is the most concerning hematologic effect of MTX?
Pancytopenia
CrCl less than what should make you think twice before using MTX?
CrCl < 50
In general a liver biopsy should be performed after what cumulative dose of MTX?
1.5grams