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27 Cards in this Set
- Front
- Back
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*Heriditary spherocytosis
-warm AIHA -old blood -burns -venoms -oxidant damage |
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*Iron deficiency
-non-specific |
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Echinocytes (burr cells)
*Renal failure -prolonged EDTA -low pH slides -pyruvate kinase deficiency -post splenectomy |
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Acanthocytes (spur cells)
*liver disease *Mcleod phenotype (no Kx) -ab-lipoproteinemia -hypothyroidism -post spenectomy -myelodysplastic syndrome |
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Codocytes (Target cells)
*HbC (clam cells) -liver disease -asplenia -iron deficiency |
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Echinocytes (burr cells)
*Renal failure -prolonged EDTA -low pH slides -pyruvate kinase deficiency -post splenectomy |
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Bite cells
*G6PD deficiency |
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Basophilic stippling
-reflects RNA/RNA-complexes *lead poisoning *pyrimidine 5' nucleosidase deficiency -hemoglobinopathies -myelodysplasia -infection -sideroblastic anemia -porphyria |
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Heinz body
-requires crystal violet *G6PD deficiency -bite cells have had them bitten out |
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Howell Jolly Body
-nuclear remnant *post splenectomy -functional asplenia (many causes) -megaloblastic anemia -myelodysplasia |
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Pappenheimer Body
-reflect iron *iron overload -postsplenectomy/asplenia -confirm on Fe stain |
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Rouleaux
-due to loss of normal RBC repulsion *immunoglobulin *fibrinogen -ESR = equivalent phenomenon |
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Autoagglutination
*due to cold agglutinins -typically IgM autoantibody -EBV -mycoplasma -increases MCV -decreases RCC -correct by warming |
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Plasmodium falicparum
-headphone rings -bananas (gametocytes) |
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Babesiosis
-tetrad of four meroziites -resembles maltese cross -unlike malaria, don't see schozonts, gametocytes, or pigment -Ixodes dammini |
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Babesiosis
-tetrad of four meroziites -resembles maltese cross -unlike malaria, don't see schozonts, gametocytes, or pigment -Ixodes dammini |
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Babesiosis
-tetrad of four meroziites -resembles maltese cross -unlike malaria, don't see schozonts, gametocytes, or pigment -Ixodes dammini |
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B-thal major
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B thal minor
-increased HbA2 -MCV/RCC ratio greater than 10 -ddx Fe deficiency |
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Rouleaux
-due to loss of normal RBC repulsion *immunoglobulin *fibrinogen -ESR = equivalent phenomenon |
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Alpha thal (golf balls)
-Hb H -B4 tetramers -brilliant cresyl blue stain |
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Positive HAM test
-PNH -PIGA -lack GPI anchor -DAF(CD55) -MIRL(CD59) -susceptible to complement lysis |
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Megaloblastic anemia:
-macroovalocytes -tear drop poikilocytes -Howell-Jolly bodies macropolcytes -Hypersegmented neutrophils giant platelets -cirgulating megaloblasts |
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Megaloblastic anemia
-markedly hypercellular marrow -nuclear: cytoplasmic dissociation -karyolyisis -karyorrhexis |
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Megaloblastic anemia
-giant myelocytes -bizarrely nucleated metamyelocytes -nucleated megakaryocytes |
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What chemical test correlates with the image?
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Megablastic anemia:
-increased LDH(isoenzymes 1 and 2) secondary to intramedullary ell death and inefective hmeatopoiesis |
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Schilling Test:
Part I: B12 alone Part II: B12 plus IF Part III: with antibiotics |
