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27 Cards in this Set

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*Heriditary spherocytosis

-warm AIHA
-old blood
-burns
-venoms
-oxidant damage
*Iron deficiency

-non-specific
Echinocytes (burr cells)

*Renal failure
-prolonged EDTA
-low pH slides
-pyruvate kinase deficiency
-post splenectomy
Acanthocytes (spur cells)

*liver disease
*Mcleod phenotype (no Kx)
-ab-lipoproteinemia
-hypothyroidism
-post spenectomy
-myelodysplastic syndrome
Codocytes (Target cells)

*HbC (clam cells)
-liver disease
-asplenia
-iron deficiency
Echinocytes (burr cells)

*Renal failure
-prolonged EDTA
-low pH slides
-pyruvate kinase deficiency
-post splenectomy
Bite cells

*G6PD deficiency
Basophilic stippling
-reflects RNA/RNA-complexes

*lead poisoning
*pyrimidine 5' nucleosidase deficiency
-hemoglobinopathies
-myelodysplasia
-infection
-sideroblastic anemia
-porphyria
Heinz body
-requires crystal violet

*G6PD deficiency
-bite cells have had them bitten out
Howell Jolly Body
-nuclear remnant

*post splenectomy
-functional asplenia (many causes)
-megaloblastic anemia
-myelodysplasia
Pappenheimer Body
-reflect iron

*iron overload
-postsplenectomy/asplenia

-confirm on Fe stain
Rouleaux
-due to loss of normal RBC repulsion

*immunoglobulin
*fibrinogen

-ESR = equivalent phenomenon
Autoagglutination

*due to cold agglutinins
-typically IgM autoantibody
-EBV
-mycoplasma

-increases MCV
-decreases RCC
-correct by warming
Plasmodium falicparum

-headphone rings
-bananas (gametocytes)
Babesiosis
-tetrad of four meroziites
-resembles maltese cross

-unlike malaria, don't see schozonts, gametocytes, or pigment

-Ixodes dammini
Babesiosis
-tetrad of four meroziites
-resembles maltese cross

-unlike malaria, don't see schozonts, gametocytes, or pigment

-Ixodes dammini
Babesiosis
-tetrad of four meroziites
-resembles maltese cross

-unlike malaria, don't see schozonts, gametocytes, or pigment

-Ixodes dammini
B-thal major
B thal minor

-increased HbA2
-MCV/RCC ratio greater than 10
-ddx Fe deficiency
Rouleaux
-due to loss of normal RBC repulsion

*immunoglobulin
*fibrinogen

-ESR = equivalent phenomenon
Alpha thal (golf balls)

-Hb H
-B4 tetramers
-brilliant cresyl blue stain
Positive HAM test

-PNH
-PIGA
-lack GPI anchor
-DAF(CD55)
-MIRL(CD59)
-susceptible to complement lysis
Megaloblastic anemia:

-macroovalocytes
-tear drop poikilocytes
-Howell-Jolly bodies
macropolcytes
-Hypersegmented neutrophils
giant platelets
-cirgulating megaloblasts
Megaloblastic anemia

-markedly hypercellular marrow
-nuclear: cytoplasmic dissociation
-karyolyisis
-karyorrhexis
Megaloblastic anemia

-giant myelocytes
-bizarrely nucleated metamyelocytes
-nucleated megakaryocytes
What chemical test correlates with the image?
Megablastic anemia:

-increased LDH(isoenzymes 1 and 2) secondary to intramedullary ell death and inefective hmeatopoiesis
Schilling Test:

Part I: B12 alone
Part II: B12 plus IF
Part III: with antibiotics