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3 Cards in this Set

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What molecule is Warfarin related to?

Vitamin K




Its a analogue of K

Function of Warfarin?

A competitive-antagonist of Vit-K reductase




Prevents Y-carboxylation of precursors for a number of clotting factors


Loss of precursor, slows coagulation

A competitive-antagonist of Vit-K reductase






Prevents Y-carboxylation of precursors for a number of clotting factors




Loss of precursor, slows coagulation



Problems with warfarin?

  • Slow Onset

Pre-existing factors need to be depleted


Rate of depletion varies





  • Activity influenced/ Affected by Vit K

Competitve molcules


Vit K affected by intake, gut flora etc, many factors





  • Warfarin Exists as R, S Isomers

Activity for each of the Enantomers differs in metabolism





  • Risk of Haemorrhage:

Mild: Stop dosage


Severe: Give Vit K factors, and whole blood





  • Teratogenic

Can cause birth defects, avoid in early pregnancy





  • Drug interaction through:

Enzyme inhibiton and activation, displacement from carrier proteins




Transported on carrier proteins in blood as free warfarin is dangerous