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3 Cards in this Set
- Front
- Back
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What molecule is Warfarin related to? |
Vitamin K Its a analogue of K |
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Function of Warfarin? |
A competitive-antagonist of Vit-K reductase Prevents Y-carboxylation of precursors for a number of clotting factors Loss of precursor, slows coagulation |
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Problems with warfarin? |
Pre-existing factors need to be depleted Rate of depletion varies
Competitve molcules Vit K affected by intake, gut flora etc, many factors
Activity for each of the Enantomers differs in metabolism
Mild: Stop dosage Severe: Give Vit K factors, and whole blood
Can cause birth defects, avoid in early pregnancy
Enzyme inhibiton and activation, displacement from carrier proteins Transported on carrier proteins in blood as free warfarin is dangerous |
