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57 Cards in this Set
- Front
- Back
Na+ Channels
(Depolarization/Hyperpolarization) |
Depolarization
|
|
K+ Channels
(Depolarization/Hyperpolarization) |
Hyperpolarization
|
|
Cl- Channels
(Depolarization/Hyperpolarization) |
Hyperpolarization
|
|
Ca2+ Channels
(Depolarization/Hyperpolarization) |
Depolarization
|
|
Chloride is going to generate an _______ current and cause _________ of membrane potential.
|
Inward
Hyperpolarization |
|
Potassium is going to generate an _________ current and cause __________ of the membrane potential.
|
Outward
Hyperpolarization |
|
Voltage-Dependent K+ Channels
|
IA
ID IK IM |
|
Rectifier K+ Channels
|
IK
Anomalous IH Tandem Pore |
|
Metabotropic-gated K+ Channels
|
IM
IATP IAHP IsAHP |
|
Calcium-dependent K+
|
IC
IM IAHP IsAHP |
|
VDKCs:
IA Channel (HVA/LVA) (FI/SI/NI) |
LVA
FI |
|
VDKCs:
ID Channel (HVA/LVA) (FI/SI/NI) |
LVA
FI |
|
VDKCs:
IK Channel (HVA/LVA) (FI/SI/NI) |
HVA
SI |
|
VDKCs:
IM Channel (HVA/LVA) (FI/SI/NI) |
LVA
NI |
|
Voltage-Dependent conformational movement of negatively charged portions of the alpha subunit ___________ K+ influx.
|
Activates
|
|
Inactivation involves voltage-dependent binding of any 1 of 4 positively charged "ball and chain" portion of th beta subunit to ______ K+ influx.
|
Block
|
|
The IM channel lacks the ________ subunit thus it is non-inactivating.
|
Beta
|
|
The anomalous rectifier and the IH(Q) channels contain ______ separate subunits with _______ transmembrane segments.
|
Four
Two |
|
The tandem pore channels contain _______ subunits with ________ transmembrane segments, these transmembrane segments come together as sets of four and along with another set of four. The dimerize together and form ______ pores.
|
Four
Four Two |
|
Rectifying Channels:
IK Channel (HVA/HA/LVA) (FI/SI/NI) |
HVA
SI |
|
Rectifying Channels:
Anomalous Channel (HVA/HA/LVA) (FI/SI/NI) |
HA
SI |
|
Rectifying Channels:
IH(Q) Channel (HVA/HA/LVA) (FI/SI/NI) |
HA
SI |
|
Rectifying Channels:
Tandem Pore Channel (HVA/HA/LVA) (FI/SI/NI) |
SI
|
|
The anomalous rectifier and the IH(Q) channels ate going to generate an _________ current of potassium and cause _________ of the membrane potential.
|
Inward
Depolarizationn |
|
Volatile Anesthetics tend to turn on the ________ channels.
|
Tandem Pore
|
|
CaM is the Ca2+ sensor for the _______ channels.
|
IAHP
|
|
CaM remains bound to the AHP channels even when theres is not any Ca2+ bound to CaM. This is known as ________ binding.
|
Constitutive
|
|
What is the toxin which will bind to the extracellular face of the SK-channels and prevent K+ ions from flowing out of them?
|
Apamin
|
|
Hippocalcin is a CBP that is going to act as a calcium sensor for the ______ channels.
|
sAHP
|
|
Hippocalcin is not as sensitive to calcium as CaM, it is going to bind _______ calcium as opposed to four.
|
Three
|
|
True or False:
Hippocalcin remains constitutively bound to the sAHP channels. |
False.
|
|
CDKCs:
IM channels (Fast-AHP/Medium-AHP/Slow-AHP/Not Applicable) |
N/A
|
|
CDKCs:
IC channels (Fast-AHP/Medium-AHP/Slow-AHP/Not Applicable) |
Fast-AHP
|
|
CDKCs:
IAHP (Fast-AHP/Medium-AHP/Slow-AHP/Not Applicable) |
Medium-AHP
|
|
CDKCs:
IsAHP (Fast-AHP/Medium-AHP/Slow-AHP/Not Applicable) |
Slow-AHP
|
|
CDKCs:
IAHP channels (CaM/Hippocalcin) |
CaM
|
|
CDKCs:
IsAHP channels (CaM/Hippocalcin) |
Hippocalcin
|
|
CDKCs:
IM channels (FI/SI/NI) |
SI
|
|
CDKCs:
IC channels (FI/SI/NI) |
FI
|
|
CDKCs:
IAHP channels (FI/SI/NI) |
NI
|
|
CDKCs:
IsAHP channels (FI/SI/NI) |
NI
|
|
Chlorotoxin
|
Cl- channels
|
|
Retigabine
|
IA channels
IM channels |
|
DTX
|
IA channels
ID channels IK channels |
|
Halothane
|
Tandem pore channels
|
|
Isoflurane
|
Tandem pore channels
|
|
Acetylcholine
|
IM channels
|
|
ATP
|
IATP channels
|
|
Apamin
|
IAHP channels
|
|
Niflumate
|
IC channels
|
|
Tamoxifen
|
Cl- channels
|
|
Minoxidil
|
ID channels
|
|
Cesium Ions
|
IA channels
ID channels IK channels IM channels Anomalous channels IH(Q) channels |
|
Linopiridine
|
IM channels
|
|
Dequalinium
|
IAHP channels
|
|
Charybdotoxin
|
IC channels
|
|
Calcium Ions
|
IAHP channels
IsAHP channels |