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10 Cards in this Set

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  • Back
What class of virus is influenza and what are its chief characteristics?
Orthomyxoviridae, Group V, 3 types - A, B, C, able to mutate and so antigenic drift and shift occurs, segmented genomes
How does influenza bind to the cell?
H protein attaches to sialic acid, endosomal entry, low pH membrane fusion
What are some of the important differences between influenza A, B, and C?
A - humans, pigs, horses, other mammals, birds, B - humans only, C - humans, pigs
What are the concerns of H5N1?
avian flu - jumped from birds to humans, only H5 to infect humans, 33% fatality, single insertion could cause spread to brain and heart
Why are the young and very old most susceptible to Influenza?
young - croup, otitis, secondary bacterial infxn, very old - pneumonia, secondary bacterial infxn, preexisting conditions exacerbated
What does influenza do to the lungs?
it destroys the cilia of ciliated columnar epithelium destroying cleaning system of lungs - mucus builds up
How is influenza spread? How many particles are sneezed or coughed out?
respiratory droplets, 100,000 to 1 million viruses per droplet
Where does the influenza virus replicate and what are its unique features for taking over the cell?
in nucleus, exploits host nuclear splicing for viral mRNA, suppresses interferon release
When were major influenza epidemics?
1918-1919 - Spanish flu, 1957-1958 - Asian flu, 1968-1969 - Hong Kong flu
Where and how do new strains of influenza develop?
influenza A viruses from swine and avian infect same cell creating antigenic shift