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17 Cards in this Set
- Front
- Back
describe the structure and biological properties of Poxiviridae.
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enveloped
complex morphology larger, linear, ds-DNA genome |
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what human viruses are caused by the family Poxiviridae
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Variolla (small pox)
Molluscum contagiosum |
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What are the zoonotic viruses caused by Poxiviridae?
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Vaccinia
Cowpox Orf Monkeypox |
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describe small pox pathology
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1. respiratory virus infects URT
2. Carried through lymphatic system to lymph node by macrophages (cell-associated viremia) 3. replication at site causes 2nd viremia that spreads the virus throughout the body and produces characteristic rash 4. cell mediated immunity is important |
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True or False
Smallpox is very contagious and infections spread by respiratory routes as well as direct contact. |
True
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How many serotypes are found for smallpox?
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1
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True or False
the dried small pox virus is still infectious |
True
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Are humans the only host for small pox?
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yes
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Would the infection or the immunization produce lifelong immunity?
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YES
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how is smallpox clinically diagnosed?
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diagnosed clinically by characteristic pox marks
-an inclusion body called Gyamjeri body can be seen in the infected cells |
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What is the treatment for a patient diagnosed with smallpox?
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Vaccinia immune globulin is the first line of defense
Cidofovir is the second line of therapy |
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what are some of the major differences between smallpox and chickenpox in the prodromal phase of disease?
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Smallpox:
1. onset of fever begins as an integral part of the prodromal phase 2. Fever appears 2-4 days before the rash appears 3. constitutional symptoms: severe prostration, abdominal pain, back pain, delirium Chickenpox 1. patient with chickenpox usually have NO fever or other prodromal findings prior to onset of rash |
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Describe the difference between smallpox lesions and chickenpox lesions.
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Smallpox:
initial lesions appear on the face, in mouth, & pharynx, & forearms. - Smallpox lesions tend to have greatest concentration on arms, legs, palms, and soles -smallpox lesions progress through Stages of Evolution at the same rate **** all lesions in same developmental stage -smallpox lesions progress much more slowly typically 1-2 days for each stage |
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Describe the difference between smallpox lesions and chickenpox lesions.
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Chickenpox:
rash for chickenpox has centripetal distribution with more lesions on the trunk, with the hands & soles exhibiting few to none lesions Chickenpox lesions are present in all stages at any single location Chickenpox lesions may crust over within 24 hours after the initial macule appears |
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Name other viruses caused by Poxiviridae.
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Molluscum Contagiosum
Vaccinia cowpox orf monkeypox |
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What is a common name given to Vaccinia?
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Milker's nodules because it is caused by cowpoxs
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What is an interesting fact about Vaccinia?
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original virus to prevent smallpox
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