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26 Cards in this Set
- Front
- Back
amantidine, which is effective against ___, targets ___, which is a ___. this inhibits ___
|
influenza A
M2 ion channel uncoating |
|
anti-HSV drugs (3)
|
ara-A
acyclovir foscarnet |
|
ara-A is a ___. it is used against ___
it acts by ___ (2) |
adenine analog
HSV encephalitis inhibiting viral DNA pol inserting into viral DNA |
|
acyclovir is a ___
|
guanosine analog
|
|
acyclovir is effective against both ___ and ___. a higher dose is required for ___
|
HSV
VZV VZV |
|
anti-CMV drugs (2)
|
ganciclovir
foscarnet |
|
ganciclovir is a ___
|
guanosine analog
|
|
NRTIs
|
AZT
ddI ddC |
|
___ are a group of endogenous antiviral molecules.
|
IFNs
|
|
T/F: IFNs are pre-synthesized and released in response to infection
|
false: synthesized de novo
|
|
T/F: IFN released against virus x also helps fight virus y
|
true
|
|
IFNa is synthsized by ___. there are ___ loci.
|
leukocytes
15 |
|
IFNb is synthesized by ___. there are ___ loci.
|
fibroblasts
1 |
|
IFNg is synthesized in ___. it has ___ loci
|
lymphocytes
1 |
|
___ has the highest antiviral activity
|
IFNa
|
|
___ is the strongest IFN inducer. it causes the ___ to dissociate from the IFN DNA
|
dsDNA
repressor |
|
signalling from IFNRs is directed at ___, which produce ___
|
interferon response sequence (IRS)
interferon regulated proteins (IRPs) |
|
T/F: IRPs block viral replication at multiple steps
|
true
|
|
IRP examples
|
dsRNA dependent 2'-5' oligo A synthetase
PKR ADAR mx1 |
|
2'-5' oligo A synthetase works on ___ viruses. it works by ___ which ___s.
|
+ sense ssRNA
activating RNAse L cleaves viral ssRNA |
|
PKR mechanism
|
inactivating phosphorylation of eIF-2a
prevents synthesis of viral proteins |
|
___ synthesizes PKR inhibitors
|
adenovirus
|
|
MX proteins work on ___. the work by ___ing (3)
|
RNA viruses.
associating with nucleocapsid inhibiting nuclear transport inhibiting transcription |
|
IFN has been used to fight ___ (3) with modest success
|
HBV
HCV CMV |
|
viruses inhibit IFN defense by (4)
|
inhibiting IFN synthesis
making decoy receptors inhibiting IFN signalling interfering with IRPs |
|
viruses which inhibit IFN signalling (2)
|
polyoma
adenovirus (E1A) |