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12 Cards in this Set
- Front
- Back
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what is iron bound to in the blood? What is the normal range for iron?
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transferrin.
50-150 mcg/dL |
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What is TIBC? What are the normal values for TIBC?
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Total Iron Binding Capacity. TIBC is an indirect measure of circulating ferritin. Measures iron's ability to bind transferrin.
TIBC = 300-360 mcg/dL |
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What is transferrin saturation (the formula)? What is the normal value?
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The formula is:
serum iron / TIBC x 100. Normally 25-50% |
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What transferrin saturation level is associated with iron-deficiency anemia?
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transferrin saturation < 18%
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In evaluating the serum iron, the clinician should be aware that there is a ______ variation in the value
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In evaluating the serum iron, the clinician should be aware that there is a DIURNAL variation in the value
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What does a transferrin saturation of > 50% imply? What are the implications of this?
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A disproportionate amount of iron bound to transferrin is being delivered to nonerythroid tissues. If this exists for an extended period of time, tissue iron overload could occur.
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How is iron stored intracellularly?
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complexed to protein as ferritin or as hemosiderin
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What binds free ferous iron? What state is it stored in?
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Apoferritin binds to free ferous iron and stores it in the ferric state.
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What is the most convenient way to estimate total body iron stores?
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Under steady-state conditions, the serum ferritin level correlates with total body iron stores; thus, the serum ferritin level is the most convenient laboratory test to estimate iron stores.
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The normal range of ferritin varies to due what 2 variables? What are the normal ranges?
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Age and gender
Adult males: around 100 mcg/dL Adult females: around 30 mcg/dL |
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What serum ferritin level correlates with "absent body iron stores"?
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Serum ferritin < 15 mcg/dL
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What are causes of increased transferrin?
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Iron-deficiency anemia and OCP/pregnancy.
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