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45 Cards in this Set
- Front
- Back
What disease(s) is a/w HLA subtype A3?
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Hemochromatosis
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What disease(s) is a/w HLA subtype B27?
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PAIR
- Psoriasis - Ankylosing spondylitis - IBD - Reiter's/Reactive Arthritis |
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What disease(s) is a/w HLA subtype B8?
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Grave's Dz
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What disease(s) is a/w HLA subtype DR2?
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MS
SLE Goodpasture's Hay fever (allergies) |
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What disease(s) is a/w HLA subtype DR3?
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DM1
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What disease(s) is a/w HLA subtype DR4?
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DM1
RA |
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What disease(s) is a/w HLA subtype DR5?
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Pernicious Anemia (& B12 def)
Hashimoto's thyroiditis |
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What disease(s) is a/w HLA subtype DR7?
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Steroid-responsive Nephrotic Syndrome
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Which are the live attenuated vaccines?
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Sabin (Polio)
Yellow Fever MMR Chicken Pox (Varicella) I'm SABIN' a lot of $ by going to the YMC-A |
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Which are the killed / inactivated vaccines?
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- Cholera
- HAV - Influenza - Rabies - Polio (SALK) you won't hear a CHIRP (or a SULK) outta them |
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What marker is used to detect mast cell degranulation (for e.g. in an anaphylactic reaction)?
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Tryptase = serine protease
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What disorder is a/w anti-Smith Ab's?
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SLE
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What disorder is a/w Antihistone Ab's?
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Rx-induced Lupus
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What disorder is a/w Anti-IgG Ab's?
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RA
(="rheumatoid factor") |
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What disorder is a/w Anticentromere Ab's?
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Scleroderma (CREST)
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What disorder is a/w Anti-DNA topoisomerase I?
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Scleroderma (diffuse)
(=Anti-Scl-70) |
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What disorder is a/w Antimitochondrial Ab's
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PBC
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What disorder is a/w Antiendomysial Ab's?
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Celiac disease
Also Antigliadin |
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What disorder is a/w Anti-BM Ab's?
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Goodpasture's syndrome
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What disorder is a/w Anti-desmoglein Ab's?
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Pemphigus vulgaris
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What disorder is a/w Antimicrosomal Ab's?
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Hashimoto's thyroiditis
Also Antithyroglobulin |
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What disorder is a/w Anti-Jo-1?
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Polymyositis
Dermatomyositis |
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What disorder is a/w Anti-SS-A and Anti-SS-B Ab's?
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Sjogren's syndrome
A = Ro B = La |
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What disorder is a/w Anti-U1 RNP?
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Mixed Connective Tissue Disease (MCTD)
RNP = ribonucleoprotein |
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What disorder is a/w Anti-Smooth Muscle?
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Autoimmune hepatitis
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What disorder is a/w Anti-glutamate decarboxylase?
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DM 1
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What disorder is a/w c-ANCA?
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Wegener's Granulomatosis
cytoplasmic-AntiNeutrophil Cytoplasmic Ab |
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What disorder is a/w p-ANCA?
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Vasculitides:
- Mycroscopic Polyangitis - Churg-Strauss |
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What bacteria are you most susceptible to if you are lacking complement?
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Neisseria
b/c there's no Membrane Attack Complex (MAC) |
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What infections are you prone to w/ agranulocytosis?
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Bacteria = Staph & Pseudomonas
Fungi = Candida & Aspergillus |
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What is aldesleukin used for?
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It's an IL-2 analog used for:
- RCC - Metastatic Melanoma |
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What is Filgrastim used for?
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Granulocyte colony stimulating factor analog (GCSF)
Stimulates Bone Marrow (post chemo) |
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What is Sargramostim used for?
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Granulocyte macrophage colony stimulating factor analog
used for Bone marrow stimulation (following chemo) |
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What diseases is IFN-α used to Tx?
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HBV
HCV KS AML & CML Malignant Melanoma |
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What disease is IFN-ß used to Tx?
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MS
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What disease is IFN-Γ used to Tx?
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CGD
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What recombinant cytokines are sued to treat Thrombocytopenia?
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Thrombopoeitin
Oprelvekin (IL-11 analog) |
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Which mab's target TNF-α and what is their application?
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Infliximab
Adalimumab Tx the Seronegative Spondylarthropathies & RA NOT Reactive Arthritis NOTE: Inflix = only for AS |
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What is the target for Abciximab?
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G IIb/IIIa
Prevents cardiac ischemia in: - Unstable angina - Percutaneous coronary interventions |
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What is the target of Trastuzumab?
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aka HERceptin
Targets erb-B2 Used to tx HER-2 overexpressing breast cancers |
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What is the target of Rituximab?
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CD20 (expressed on B-Cells)
Tx for B-cell NHL |
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What is the target for Omalizumab?
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IgE
Used for severe asthma |
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What are the calcineurin inhibitors and what are they used for?
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Cyclosporine
Tacrolimus Inhibit IL2 and used in post-transplant and autoimmune diseases VERY nephrotoxic!` |
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How is mTOR involved in immunosuppression?
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Sirolimus = Rapamycin
Forms a complex w/ FKBP12 and blocks mTOR. This prevents TCell's from responding to IL-2 secretion. |
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What mab's are useful in transplant immunosuppression?
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Daclizumab = Dac-LI-2-umab
- binds IL2-R Muromonab = OKT3 - binds CD3 |