Related Essays

  • Chediak Higashi Syndrome Research Paper

    The defect prevents phagocytes from destroying what they engulf and Giant Granules of undigested material builds up. This causes recurrent infection (impaire...

  • Chediak-Higashi Syndrome Analysis

    These alterations include neutropenia, which may be profound; decreased deformability, resulting in impaired chemotaxis; and delayed phagolysosomal fusion, r...

  • Cancer Therapy Research Paper

    Paclitaxel has the ability to polymerize tubulin in the absence of cofactors such as guanosine triphosphate. The microtubule cytoskeleton reacts to paclitaxe...

  • 1. What Are The Various Phases That Make Up The Cell Cycle?

    (3 marks) The Biology Project indicates that the cell cycle uses CDKs and Cyclins (G1 and Mitotic) for regulation: Cyclin-Dependent Kinase (CDK) is an enzym...

  • Cyclin-Dependent Bonds And Protein Analysis

    There are two key types of regulatory molecules that control a cell's progress through the cell cycle, (1) the cyclin-dependent kinases and (2) several diffe...

  • Albinism Research Paper

    Various forms of the condition exist. Hermansky-Pudlak Syndrome and Chediak-Higashi Syndrome are both rare variations of the condition which cause bleeding d...

  • What Are The Three Stages Of The Cell Cycle Overview

    Cell cycle overview The role of the cell cycle is to allow a cell to increase its mass, acquire nutrients, duplicate DNA and divide into daughter cells. Th...

  • Mitosis Lab Report

    Using this set, we had to arrange the different phases into the appropriate order of mitosis. Once we finished rearranging the phases into their appropriate ...

  • Cell Cycle Checkpoints

    The checkpoints in the cell cycle There are several checkpoints the eukaryote cell cycle that controls the cells from proceeding from one to the next phase o...

  • Deoxyribonucleic Acid Vs Dna Research Paper

    During this process the genetic material is passed from one cell to another. Mitosis involves a four-stage process; prophase, metaphase, anaphase, and telop...

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

Card Range To Study

through

image

Play button

image

Play button

image

Progress

1/7

Click to flip

Use LEFT and RIGHT arrow keys to navigate between flashcards;

Use UP and DOWN arrow keys to flip the card;

H to show hint;

A reads text to speech;

7 Cards in this Set

  • Front
  • Back
How are cyclins broken down?
Cyclins are broken down by ubiquitin protein ligase.
What bind and inactivate Cyclin-CDK complexes?
p57
p27
p21
(p53 regulates p21)
What happens to progress from G1 → S Phase in the cell cycle?
1) CycD/CDK4 phosphorylate Rb

2) Rb releases E2F transcription factor

3) Cell produces:
- CycE
- DNA Polymerase
- DHFR
- Thymidine kinase

4) CycE/CDK2 bind → S Phase
What happens to progress from G2 → Mitosis?
1) CycA/CDK2 initiate Prophase

2) cdc25 activates CycB/CDK1

3) CycB/CDK1:
- breakdown nuclear lamin / envelope
- initiate mitosis
What are nuclear localization signals and how do they work?
4-8 amino acid segments rich in positive aa's = Lys, Arg, Pro

Are recognized by nuclear pores and allow the activation of ATPase to move molecule (e.g. histone) into the nucleus
What are the drugs that act on microtubules?
Prescribe Micro-Tubule Growth Voiding Chemicals:
P - Paclitaxel (anti-breast ca)
M - Mebendazole (anti-helminth)
T - Thiabendazole (anti-helminth)
G - Griseofulvin (anti-fungal)
V - Vincristine/vinblastine (anti-ca)
C - Colchicine (anti-gout)
What are the characteristics of Chediak-Higashi syndrome?
MT polymerization defect → problems w/ phagosomes/lysosomes

PPPAIN
- Partial Albinism
- Pyogenic Infections
- Peripheral Neuropathy