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45 Cards in this Set
- Front
- Back
Where are the majority of adult primary tumors located?
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Supratentorial
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Where are the majority of childhood primary tumors located?
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Infratentorial
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What are the most common adult tumors in the brain? Describe appearance/location.
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Metastatses; well circumscribed; usually present at gray-white jct
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Major adult primary brain tumors
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Glioblastoma multiforme (grade IV astrocytoma)
Meningioma Schwannoma Oligodendroglioma Pituitary adenoma |
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Major childhood primary tumors
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Pilocytic (low grade) astrocytoma
Medulloblastoma Ependymoma Hemangioblastoma Craniopharyngioma |
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Most common primary brain tumor in adults
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Glioblastoma multiforme
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Most common location for glioblastoma multiforme
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Cerebral hemispheres
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Expected life expenctancy for glioblastoma multiforme
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Less than 1 yr
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Histology of glioblastoma multiforme
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"pseudopalisading" pleomorphic tumor cells-border central areas of necrosis and hemorrhage
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Gross appearance of glioblastoma multiforme
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"butterfly glioma" can cross corpus callosum
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2nd most common primary brain tumor in adults
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Meningioma
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Most common location for meningioma
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Convexities of hemispheres and parasagittal region
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Origin of cells in meningiomas
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Arachnoid cells external to brain
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Treatment for meningiomas
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Resectable
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Histology of meningioma
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Spindle cells concentrically arranged in a whorled pattern; psammoma bodies (laminated calcifications)
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3rd most common primary brain tumor in adults
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Schwannoma
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Most frequent location of schwannoma
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CN VIII at cerebellopontine anglek
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Treatment for schwannoma
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Resectable
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Bilateral acoustic schwannomas pathognomonic for?
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Neurofibromatosis type II
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Most common location for oligodendroglioma
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Frontal lobes
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Histology of oligodendroglioma
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Chicken wire capillary pattern
"fried egg appearance"-round nuclei w/clear cytoplasm; often calified |
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Most common type of pituitary adenoma
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Prolactinoma
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Common symptoms of pituitary adenoma
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Bitemporal hemianopia due to pressure on optic chiasm
Hyper or hypopituitarism as sequelae |
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Location of pituitary adenoma
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Rathke's pouch
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Most common location of pilocytic astrocytoma in children
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Posterior fossa; may be supratentorial
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Gross appearance of pilocytic astromcytoma
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Well circumscribed
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Prognosis for pilocytic astrocytoma
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Benign; good prognosis
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Histology of pilocytic astrocytoma
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Rosenthal fibers-eosinophlic corkscrew fibers
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Medulooblastoma; origin/location and behavior
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Highly malignant cerebellar tumor; neuroectodermal origin
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Medulloblastoma: common sequelae
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Can compress 4th ventricle causing hydrocephalus
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Medulloblastoma histology
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Blue, small round cells w/pseudorosettes
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Treatment f medulloblastoma
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Radiosensitive
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Cellular marker for GBM and pilocytic astrocytoma
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GFAP
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Ependymoma most common location
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4th ventricle
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Common presentation of ependymoma
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Hydrocephalus
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Prognosis for ependymoma
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Poor
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Histology of ependymoma
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Perivascular pseudorosettes; rod-shaped blepharoplasts (basal ciliary bodies) found near nucleus
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Mot common location for hemangioblastoma
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Cerebellar
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Disease associated with hemangioblastoma
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Von Hippel Lindau syndrome w/retinal angiomas
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Hormone that can be produced from hemangioblastoma and neoplastic effect
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Can produce EPO causing secondary polycythemia
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Histology of hemangioblastoma
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Foamy cells and high vascularity
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Common symptoms of craniopharyngioma
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Bitemporal hemianopia
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Most common supratentorial tumor
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Craniopharyngioma (benign childhood tumor)
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Histology of craniopharyngioma
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Calficiation common (tooth enamel like)
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Derivation of craniopharyngioma
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Rathke's pouch derived
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